Regulation of mTORC1 by growth factors, energy status, amino acids and mechanical stimuli at a glance.
Regulation of mTORC1 by growth factors, energy status, amino acids and mechanical stimuli at a glance.
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DOI：
10.1186/s12970-016-0118-y
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发表时间：
2016
影响因子：
5.1
通讯作者：
Bond P
中科院分区：
文献类型：
--
作者：
Bond P
雷帕霉素复合体1 （mTORC1）的机制/哺乳动物靶点在骨骼肌蛋白合成的调控中起关键作用。该复合物的激活导致两组重要底物的磷酸化，即eIF4E结合蛋白和核糖体S6激酶。这些底物的磷酸化随后导致蛋白质合成的增加，主要是通过增强翻译起始。mTORC1活性受多种输入调控，如生长因子、能量状态、氨基酸和机械刺激。该领域的研究正在迅速发展，并揭示了这些输入如何调节复合物。因此，这篇综述试图提供一个简短的和最新的叙述对这个奇妙的蛋白质复合物的调节。此外，本文还讨论了一些运动补充剂对mTORC1活性的调节作用。
The mechanistic/mammalian target of rapamycin complex 1 (mTORC1) plays a pivotal role in the regulation of skeletal muscle protein synthesis. Activation of the complex leads to phosphorylation of two important sets of substrates, namely eIF4E binding proteins and ribosomal S6 kinases. Phosphorylation of these substrates then leads to an increase in protein synthesis, mainly by enhancing translation initiation. mTORC1 activity is regulated by several inputs, such as growth factors, energy status, amino acids and mechanical stimuli. Research in this field is rapidly evolving and unraveling how these inputs regulate the complex. Therefore this review attempts to provide a brief and up-to-date narrative on the regulation of this marvelous protein complex. Additionally, some sports supplements which have been shown to regulate mTORC1 activity are discussed.