Reorganization of the nuclear envelope during open mitosis.

Reorganization of the nuclear envelope during open mitosis.
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DOI:
10.1016/j.ceb.2008.09.010
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发表时间:
2008-12
影响因子:
7.5
通讯作者:
Hetzer MW
Hetzer MW
中科院分区:
生物学2区
文献类型:
--
作者:
Kutay U;Hetzer MW

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核膜(NE)在细胞核内部和细胞质之间提供选择性屏障,并构成细胞内结构的中心组成部分。在后生动物的有丝分裂过程中,NE分解,导致核内容物与胞质溶胶完全混合。有趣的是,许多NE组分积极参与有丝分裂进程。染色体分离后,NE在去致密染色质周围重新组装,并在子细胞中重新建立核区室。在这里,我们总结了最近的进展,在破译细胞分裂过程中NE动力学的分子机制。
The nuclear envelope (NE) provides a selective barrier between the nuclear interior and the cytoplasm and constitutes a central component of intracellular architecture. During mitosis in metazoa, the NE breaks down leading to the complete mixing of the nuclear content with the cytosol. Interestingly, many NE components actively participate in mitotic progression. After chromosome segregation, the NE is reassembled around decondensing chromatin and the nuclear compartment is reestablished in the daughter cells. Here, we summarize recent progress in deciphering the molecular mechanisms underlying NE dynamics during cell division.
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