The importance of continued endocrine treatment during chemotherapy of hormone-refractory prostate cancer.
The importance of continued endocrine treatment during chemotherapy of hormone-refractory prostate cancer.
复制标题
激素难治性前列腺癌化疗期间持续内分泌治疗的重要性。
作者：
D. Chao;S. Harland
目的
目前尚不清楚在难治性前列腺癌中继续雄激素剥夺是否有任何益处。我们在此报告3例持续雄激素剥夺对维持化疗反应至关重要的病例。
结果
在3例患者中，通过前列腺特异性抗原水平评估，复发前对化疗有初步反应。然而，重新开始以前无效的激素治疗导致对化疗的持续反应。
结论
在某些患者中，持续的雄激素剥夺对化疗的反应至关重要。据推测，在复发性疾病中，很大一部分肿瘤仍然对雄激素剥夺有反应。
OBJECTIVE
It is unclear if continuing with androgen deprivation in hormone-refractory prostate cancer is of any benefit. We report here 3 cases where continuation of androgen deprivation was essential in maintaining the response to chemotherapy.
RESULTS
In the 3 patients there was an initial response to chemotherapy before relapse, as assessed by prostate-specific antigen levels. However, restarting the previously ineffective hormone therapy resulted in continued response to chemotherapy.
CONCLUSIONS
In some patients continued androgen deprivation is essential to the response to chemotherapy. Presumably, in hormone-relapsed disease a significant proportion of the tumour can still be responsive to androgen deprivation.