Discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins.
Discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins.
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奥克替醇型皂苷的发现、半合成、生物活性和代谢
DOI：
10.1016/j.jgr.2017.01.001
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发表时间：
2017-07
影响因子：
6.3
通讯作者：
Meng Q
中科院分区：
文献类型：
--
作者：
Liu J;Xu Y;Yang J;Wang W;Zhang J;Zhang R;Meng Q
Ocotillol型皂苷是一类四环三萜类化合物，共有一个四氢呋喃环。在西洋参中发现了天然的ocotillol型皂苷，人参，花旗参，越南人参。近年来，有20个（S/R）-ocotillol型皂苷的半合成报道。ocotillol型皂苷的生物活性包括神经保护作用、抗心肌缺血作用、抗炎作用、抗菌作用和抗肿瘤作用。ocotillol型皂苷因其化学结构、药理作用和立体选择性抗心肌缺血活性而受到广泛关注。本文对ocotillol型皂苷的发现、半合成、生物活性和代谢进行了综述。
Ocotillol-type saponins are one kind of tetracyclic triterpenoids, sharing a tetrahydrofuran ring. Natural ocotillol-type saponins have been discovered in Panax quinquefolius L., Panax japonicus, Hana mina, and Vietnamese ginseng. In recent years, the semisynthesis of 20(S/R)-ocotillol-type saponins has been reported. The biological activities of ocotillol-type saponins include neuroprotective effect, antimyocardial ischemia, antiinflammatory, antibacterial, and antitumor activities. Owing to their chemical structure, pharmacological actions, and the stereoselective activity on antimyocardial ischemia, ocotillol-type saponins are subjected to extensive consideration. In this review, we sum up the discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins.