CALCIUM CITRATE MARKEDLY ENHANCES ALUMINUM ABSORPTION FROM ALUMINUM HYDROXIDE
CALCIUM CITRATE MARKEDLY ENHANCES ALUMINUM ABSORPTION FROM ALUMINUM HYDROXIDE
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DOI：
10.1016/s0272-6386(12)80356-8
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发表时间：
1991-06-01
影响因子：
13.2
通讯作者：
SALUSKY, IB
中科院分区：
文献类型：
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作者：
COBURN, JW;MISCHEL, MG;SALUSKY, IB
在8名正常男性中评价了柠檬酸钙对肠铝吸收的影响，通过尿铝排泄的增加来评估。测定2天的基线尿铝排泄量;此后，受试者摄入氢氧化铝3天。在一项交叉研究中，受试者在摄入氢氧化铝（2.4 g/d）的3天内接受柠檬酸钙（950 mg，每日4次）或安慰剂。在第二个对照日和氢氧化铝摄入的第三天测量血浆铝水平。基线尿铝排泄量为0.02 ± 0.004（6.5 ± 1.1 μ g/g肌酐）和0.03 ± 0.005 μ mol/mmol肌酐（7.4 ± 1.3 μ g/g肌酐）。这些值在氢氧化铝治疗期间增加，但当柠檬酸钙与氢氧化铝一起摄入时，这些值更大。连续3天，柠檬酸钙与氢氧化铝联合给药期间的尿铝排泄水平分别为氢氧化铝单药的11.1 ± 3.23、8.8 ± 2.9和5.3 ± 0.7倍。两个治疗组的血浆铝水平无差异。因此，柠檬酸钙可显著增强氢氧化铝中铝的吸收，这两种药物不能同时用于肾衰竭患者。
The effect of calcium citrate on intestinal aluminum absorption, assessed by the increment in urinary aluminum excretion, was evaluated in eight normal men. Baseline urinary aluminum excretion was determined for 2 days; thereafter, subjects ingested aluminum hydroxide for 3 days. In a cross-over study, subjects were given either calcium citrate, 950 mg four times a day, or placebo during the 3 days of aluminum hydroxide ingestion (2.4 g/d). Plasma aluminum levels were measured on the second control day and the third day of aluminum hydroxide ingestion. Baseline urinary aluminum excretion was 0.02 ± 0.004 (6.5 ± 1.1 μg/g creatinine) and 0.03 ± 0.005 μmol/mmol creatinine (7.4 ± 1.3 μg/g creatinine). These values increased during aluminum hydroxide therapy, but values were much greater when calcium citrate was ingested with aluminum hydroxide. On 3 consecutive days, urinary aluminum excretion levels were 11.1 ± 3.23, 8.8 ± 2.9, and 5.3 ± 0.7 times greater during the administration of calcium citrate with aluminum hydroxide than with aluminum hydroxide alone. Plasma aluminum levels did not differ in the two treatment groups. Thus, calcium citrate markedly enhances the absorption of aluminum from aluminum hydroxide and the two must not be prescribed together in patients with renal failure.