Early Menarche Predicts Incidence of Asthma in Early Adulthood
Early Menarche Predicts Incidence of Asthma in Early Adulthood
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DOI：
10.1093/aje/kwq324
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发表时间：
2011-01-01
影响因子：
5
通讯作者：
Tamim, Hala
中科院分区：
文献类型：
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作者：
Al-Sahab, Ban;Hamadeh, Mazen J.;Tamim, Hala
本研究探讨了初潮年龄对成年早期哮喘发病率的影响。分析的基础是在全国儿童和青年纵向调查的前6个周期（1994-2005年）期间对8-11岁至18-21岁的加拿大女孩进行的随访。初潮早期定义为比初潮平均年龄小1个标准差。月经初潮后发生的哮喘被测量为由卫生保健专业人员诊断的哮喘。作者使用逻辑回归分析来研究初潮早与哮喘发病率之间的关系，调整可能的混杂因素。共分析了1 176名女孩，加权代表352 345名加拿大女孩。初潮后哮喘的发生率为11.2%（95%可信区间：8.3，14.0）。初潮早（< 11.56岁）可预测月经初潮后哮喘的发病率;早熟女孩在成年早期发生哮喘的风险是平均年龄成熟女孩的两倍多（比值比，2.34，95%置信区间：1.19，4.59）。目前的研究提供了全球范围内哮喘发病率迅速增加的部分见解，这与月经初潮时间下降的趋势相一致。在不同的背景下进行进一步的研究是必要的，以评估这些加拿大的调查结果的普遍性。
The present study explores the effect of age at menarche on the incidence of asthma during early adulthood. The analysis was based on Canadian girls followed up from 8-11 to 18-21 years of age during the first 6 cycles (1994-2005) of the National Longitudinal Survey of Children and Youth. Early menarche was defined as 1 standard deviation less than the average age at menarche. Asthma occurrence after menarche was measured as asthma that was diagnosed by a health care professional. The authors used logistic regression to investigate the association between early menarche and incidence of asthma, adjusting for possible confounders. A total of 1,176 girls weighted to represent 352,345 Canadian girls were analyzed. The incidence of asthma after menarche was 11.2% (95% confidence interval: 8.3, 14.0). The onset of early menarche (< 11.56 years of age) predicted postmenarcheal incidence of asthma; girls who matured early had more than twice the risk of developing asthma during early adulthood than did girls who matured at an average age (odds ratio, 2.34, 95% confidence interval: 1.19, 4.59). The present study provides partial insight into the worldwide rapid increase in asthma rates that coincides with the declining trends in menarcheal timing. Further studies within different contexts are warranted to assess the generalizability of these Canadian findings.