Hospitalized Patients With 2009 H1N1 Influenza Infection: The Mayo Clinic Experience
Hospitalized Patients With 2009 H1N1 Influenza Infection: The Mayo Clinic Experience
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DOI：
10.4065/mcp.2010.0166
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发表时间：
2010-09-01
影响因子：
8.9
通讯作者：
Afessa, Bekele
中科院分区：
文献类型：
--
作者：
Venkata, Chakradhar;Sampathkumar, Priya;Afessa, Bekele
OBJECTIVE: To describe the clinical course and outcome of adults hospitalized with the 2009 H1N1 influenza infection.PATIENTS AND METHODS: in this retrospective study, we reviewed the electronic medical records of patients with H1N1 influenza infection treated at Mayo Clinic in Rochester, MN, from May 1, 2009, through December 31, 2009.RESULTS: We identified 1053 patients with H1N1 influenza infection; this study consists of 66 hospitalized adults (6%). Patients' mean +/- SD age was 46.9 +/- 17.8 years. The 3 most common comorbidities were hypertension in 31 patients (47%), obesity In 29 (44%), and diabetes mellitus in 21 (32%). The most common symptoms were cough in 58 patients (88%), fever or chills in 55 (83%), and dyspnea in 47 (71%). Twenty-nine patients (44%) were admitted to the intensive care unit (ICU). Dyspnea and thrombocytopenia were more common in the ICU patients. The hospital, 28-day, and 90-day mortality rates were 8% (5/66), 11% (7/66), and 14% (9/66), respectively. Among the 29 ICU patients, 23 (79%) received mechanical ventilation, and 16 (55%) developed acute lung injury or acute respiratory distress syndrome. Rescue therapy for refractory respiratory failure was provided for 6 patients (21%). Of the 29 ICU patients, 10 (34%) required vasopressor support, and 4 (14%) required acute renal replacement therapy.CONCLUSION: Hospitalized adults with H1N1 Influenza infection are relatively young, and a significant number require treatment In the ICU. Among the patients who require ICU admission, most develop acute lung Injury or acute respiratory distress syndrome and require mechanical ventilator support.
