Aldehyde Detection in Electronic Cigarette Aerosols.
Aldehyde Detection in Electronic Cigarette Aerosols.
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DOI：
10.1021/acsomega.6b00489
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发表时间：
2017-03-31
期刊：
影响因子：
4.1
通讯作者：
Fu XA
中科院分区：
文献类型：
--
作者：
Ogunwale MA;Li M;Ramakrishnam Raju MV;Chen Y;Nantz MH;Conklin DJ;Fu XA
乙醛、丙烯醛和甲醛是香烟烟雾中存在的主要有毒醛类，并导致心血管疾病和非癌性肺部疾病的风险。电子烟使用的快速增长引起了人们对这些有害醛类排放的担忧。这项工作确定了这些醛的游离和结合（双醛半缩醛）形式以及使用电子烟时的其他羰基化合物的排放。采用一种新型硅微反应器，以4-（2-氨氧乙基）-吗啉-4-鎓氯化物（AMAH）为涂层相，通过肟化反应捕获电子烟气溶胶中的羰基化合物。使用气相色谱-质谱法测量AMAH-醛加合物。1H核磁共振光谱用于分析气溶胶中的半缩醛。这些醛在所有电子烟的气溶胶中都被检测到。新一代电子烟装置比第一代电子烟产生更多的醛，因为电池功率输出更高。使用较新的电子烟设备，在11.7 W及以上的电池功率输出下，在一些电子液体产生的气溶胶中检测到甲醛半缩醛。所有电子烟都排放这些醛类，特别是新一代电子烟装置排放的较高水平的醛类，表明使用电子烟的风险。
Acetaldehyde, acrolein, and formaldehyde are the principal toxic aldehydes present in cigarette smoke and contribute to the risk of cardiovascular disease and noncancerous pulmonary disease. The rapid growth of the use of electronic cigarettes (e-cigarettes) has raised concerns over emissions of these harmful aldehydes. This work determines emissions of these aldehydes in both free and bound (aldehyde–hemiacetal) forms and other carbonyls from the use of e-cigarettes. A novel silicon microreactor with a coating phase of 4-(2-aminooxyethyl)-morpholin-4-ium chloride (AMAH) was used to trap carbonyl compounds in the aerosols of e-cigarettes via oximation reactions. AMAH–aldehyde adducts were measured using gas chromatography–mass spectrometry. 1H nuclear magnetic resonance spectroscopy was used to analyze hemiacetals in the aerosols. These aldehydes were detected in the aerosols of all e-cigarettes. Newer-generation e-cigarette devices generated more aldehydes than the first-generation e-cigarettes because of higher battery power output. Formaldehyde–hemiacetal was detected in the aerosols generated from some e-liquids using the newer e-cigarette devices at a battery power output of 11.7 W and above. The emission of these aldehydes from all e-cigarettes, especially higher levels of aldehydes from the newer-generation e-cigarette devices, indicates the risk of using e-cigarettes.