Dentin and dental pulp regeneration by the patient's endogenous cells.
Dentin and dental pulp regeneration by the patient's endogenous cells.
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DOI：
10.1111/etp.12037
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发表时间：
2013-03
期刊：
影响因子：
--
通讯作者：
Mao JJ
中科院分区：
文献类型：
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作者：
Kim SG;Zheng Y;Zhou J;Chen M;Embree MC;Song K;Jiang N;Mao JJ
再生牙髓学的目标是恢复牙髓-牙本质复合体的功能。目前有两种方法用于牙髓牙本质再生：细胞移植和细胞归巢。大多数先前的方法是基于细胞移植，通过将离体培养的细胞递送到牙髓或牙本质再生。许多障碍限制了细胞移植的临床转化，例如获取和分离活细胞的困难，使用什么细胞或细胞的什么部分的不确定性，细胞操作和运输的过度成本，以及与离体细胞操作相关的免疫排斥、病原体传播和肿瘤发生的风险。相比之下，细胞归巢依赖于内源性细胞的诱导趋化性，因此规避了与细胞移植相关的许多困难。一系列的蛋白质，肽，和化学化合物，尚未被确定可能编排内源性细胞再生牙髓牙本质复合体。细胞移植和细胞归巢都是科学有效的方法;然而，细胞归巢提供了许多与牙髓牙本质再生临床治疗发展相适应的优势。
The goal of regenerative endodontics is to restore the functions of the dental pulp–dentin complex. Two approaches are being applied toward dental pulp–dentin regeneration: cell transplantation and cell homing. The majority of previous approaches are based on cell transplantation by delivering ex vivo cultivated cells toward dental pulp or dentin regeneration. Many hurdles limit the clinical translation of cell transplantation such as the difficulty of acquiring and isolating viable cells, uncertainty of what cells or what fractions of cells to use, excessive cost of cell manipulation and transportation, and the risk of immune rejection, pathogen transmission, and tumorigenesis in associated with ex vivo cell manipulation. In contrast, cell homing relies on induced chemotaxis of endogenous cells and therefore circumvents many of the difficulties that are associated with cell transplantation. An array of proteins, peptides, and chemical compounds that are yet to be identified may orchestrate endogenous cells to regenerate dental pulp–dentin complex. Both cell transplantation and cell homing are scientifically valid approaches; however, cell homing offers a number of advantages that are compatible with the development of clinical therapies for dental pulp–dentin regeneration.