Sleep deprivation reduces default mode network connectivity and anti-correlation during rest and task performance
Sleep deprivation reduces default mode network connectivity and anti-correlation during rest and task performance
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DOI：
10.1016/j.neuroimage.2011.08.026
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发表时间：
2012-01-16
期刊：
影响因子：
5.7
通讯作者：
Chee, Michael W. L.
中科院分区：
文献类型：
--
作者：
De Havas, Jack A.;Parimal, Sarayu;Chee, Michael W. L.
睡眠剥夺（SD）可以改变外在的、与任务相关的fMRI信号，涉及到注意力、记忆和执行功能。然而，其对默认模式网络（DMN）及其相关反相关网络（ACN）内固有低频连通性的影响尚未得到很好的表征。我们研究了静息状态和视觉注意任务（VAT）期间SD对DMN内功能连通性和DMN- acn反相关性的影响。26名健康参与者接受了两次功能磁共振成像：一次是在休息清醒（RW）的正常睡眠后，另一次是在大约24小时的总SD后。使用基于种子的方法来检查每个状态下不同节点的低频fMRI信号的两两相关性。SD与DMN功能连通性和DMN- acn抗相关性的显著选择性降低有关。这在静息状态和增值分析中是一致的，表明SD诱导了这些网络内部和之间内在连通性的强大改变。(C) 2011爱思唯尔公司版权所有。
Sleep deprivation (SD) can alter extrinsic, task-related fMRI signal involved in attention, memory and executive function. However, its effects on intrinsic low-frequency connectivity within the Default Mode Network (DMN) and its related anti-correlated network (ACN) have not been well characterized. We investigated the effect of SD on functional connectivity within the DMN, and on DMN-ACN anti-correlation, both during the resting state and during performance of a visual attention task (VAT). 26 healthy participants underwent fMRI twice: once after a normal night of sleep in rested wakefulness (RW) and once following approximately 24 h of total SD. A seed-based approach was used to examine pairwise correlations of low-frequency fMRI signal across different nodes in each state. SD was associated with significant selective reductions in DMN functional connectivity and DMN-ACN anti-correlation. This was congruent across resting state and VAT analyses, suggesting that SD induces a robust alteration in the intrinsic connectivity within and between these networks. (C) 2011 Elsevier Inc. All rights reserved.