The effect of continuous positive airway pressure on glucose control in diabetic patients with severe obstructive sleep apnea.
The effect of continuous positive airway pressure on glucose control in diabetic patients with severe obstructive sleep apnea.
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DOI：
10.1007/s11325-005-0033-y
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发表时间：
2005-12-01
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影响因子：
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通讯作者：
Mokhlesi, Babak
中科院分区：
文献类型：
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作者：
Hassaballa, Hesham A;Tulaimat, Aiman;Mokhlesi, Babak
阻塞性睡眠呼吸暂停 (OSA) 与葡萄糖耐受不良和胰岛素抵抗独立相关，最近的研究表明持续气道正压通气 (CPAP) 可以改善胰岛素敏感性。本研究的目的是描述 2 型糖尿病合并 OSA 患者接受 CPAP 治疗后糖化血红蛋白 (HbA1c) 的变化。为了检验这一假设，我们对某城市公立教学医院睡眠门诊的 38 名患者进行了回顾性分析。所有患者均患有OSA和2型糖尿病，并且在CPAP治疗期间其糖尿病药物治疗方案保持不变。 61% 为男性，体重指数为 42+/-9.5 kg/m(2)，呼吸暂停低通气指数为每小时 53+/-36。 CPAP 治疗前 HbA1c 为 7.8+/-1.4%，治疗 134+/-119 天后降至 7.3+/-1.3%（p
Obstructive sleep apnea (OSA) is independently associated with glucose intolerance and insulin resistance, and recent studies have shown that continuous positive airway pressure (CPAP) improves insulin sensitivity. The objective of this study was to describe the change in glycosylated hemoglobin (HbA1c) after treatment with CPAP in patients with type 2 diabetes mellitus and OSA. To test this hypothesis, we performed a retrospective analysis of 38 patients seen in the sleep clinic of an urban public teaching hospital. All patients had OSA and type 2 diabetes mellitus, and their diabetic medication regimen had remained unchanged during the period of CPAP therapy. Sixty-one percent were men, body mass index was 42+/-9.5 kg/m(2), and the Apnea-Hypopnea Index was 53+/-36 per hour. HbA1c before therapy with CPAP was 7.8+/-1.4% and decreased to 7.3+/-1.3% after 134+/-119 days of therapy (p