Antibacterial polymer scaffold based on mesoporous bioactive glass loaded with in situ grown silver
Antibacterial polymer scaffold based on mesoporous bioactive glass loaded with in situ grown silver
复制标题
基于负载原位生长银的介孔生物活性玻璃的抗菌聚合物支架
DOI：
10.1016/j.cej.2019.03.273
复制
发表时间：
2019-10-15
影响因子：
15.1
通讯作者：
Peng, Shuping
中科院分区：
文献类型：
--
作者：
Shuai, Cijun;Xu, Yong;Peng, Shuping
抗菌支架是骨科治疗中防止细菌感染的理想材料。在这项工作中，银在介孔生物活性玻璃（MBG）中原位生长，以赋予具有持续抗菌活性的聚合物支架。其中，首先通过多巴胺的氧化自聚合修饰MBG（记为pMBG）。然后，pMBG通过配位反应将银离子捕获到介孔通道中，并通过儿茶酚基的氧化还原反应将银离子原位还原为金属银。最后，利用增材制造技术将载银pMBG （Ag@pMBG）引入到聚合物基体中，构建复合支架。抑菌试验表明，复合支架具有较强的抑菌活性，对大肠杆菌的抑制环达24.2 mm，抑菌率达99%以上。此外，离子释放行为表明复合支架可以在28天内持续释放Ag。此外，复合支架还表现出良好的细胞相容性，促进成骨细胞的粘附和增殖。
An antibacterial scaffold is highly desirable to prevent bacterial infection in orthopedic treatment. In this work, silver was in situ grown in mesoporous bioactive glass (MBG) to endow a polymer scaffold with sustained antibacterial activity. In detail, MBG was firstly modified by the oxidative self-polymerization of dopamine (denoted as pMBG). Then, pMBG was used to capture silver ions into the mesoporous channel via coordination reaction and further in situ reduce silver ions to metallic silver by the redox reaction of the catechol groups. Finally, the Ag loaded pMBG (Ag@pMBG) was introduced into polymer matrices to construct composite scaffold by additive manufacturing technology. The antibacterial tests showed that the composite scaffold exhibited robust antibacterial activity with an inhibition ring of 24.2 mm and bacterial inhibition rate more than 99% against Escherichia coli. Moreover, ion release behavior demonstrated that the composite scaffold could continually release Ag over 28 days. Besides, the composite scaffold also showed good cytocompatibility in facilitating osteoblast adhesion and proliferation.