Is there any difference between the health risk from consumption of recorded and unrecorded spirits containing alcohols other than ethanol? A population-based comparative risk assessment
Is there any difference between the health risk from consumption of recorded and unrecorded spirits containing alcohols other than ethanol? A population-based comparative risk assessment
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DOI：
10.1016/j.yrtph.2019.05.020
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发表时间：
2019-08-01
影响因子：
3.4
通讯作者：
Szucs, Sandor
中科院分区：
文献类型：
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作者：
Bujdoso, Orsolya;Pal, Laszlo;Szucs, Sandor
中欧和东欧(CEE)某些国家的酒精致死死亡率仍然高于其西部邻国。没有记录的酒精消费的影响，包括自制的水果烈酒，被认为是一个解释。除了乙醇，记录和未记录的烈性酒通常还含有其他脂肪醇(OAA)。我们的目的是确定记录和未记录的烈酒中的OAA含量是否有任何差异，从而确定与其消费相关的健康风险。用气相色谱法测定记录(n=119)和未记录(n=87)烈性酒中乙醇和OAAs的浓度，并采用蒙特卡罗概率模拟方法，根据平均饮酒量、经常饮酒者和慢性重度饮酒者的饮酒量来评估风险。未记录白酒中OAA含量[中位数：9896.1 mg/L，四分位数范围：7898.3~12 634.6 mg/L]显著高于有记录白酒(中位数：975.6 mg/L，四分位数范围：136.9~4006.7 mg/L)。除了乙醇，甲醇在每个消费水平上也构成了健康风险。只有长期大量饮酒的人饮用未记录的烈性酒时，接触OAA的风险才会更高。这些发现加强了采取行动解决与消费记录和未记录的烈性酒相关的风险的重要性。
Alcohol-attributable mortality in certain countries of Central and Eastern Europe (CEE) remains higher than in their western neighbours. The effect of unrecorded alcohol consumption, including home-made fruit spirits have been suggested as an explanation. Besides ethanol, recorded and unrecorded spirits frequently contain other aliphatic alcohols (OAAs). Our aim was to ascertain whether there is any difference in the amounts of OAAs in recorded and unrecorded spirits, and thus the health risk associated with their consumption. The concentrations of ethanol and OAAs in recorded (n = 119) and unrecorded (n = 87) spirits were determined by gas chromatography and used in a Monte Carlo type probabilistic simulation to assess the risk based on average consumption level, consumption by regular drinkers and chronic heavy drinkers. The concentrations of OAAs in unrecorded spirits were significantly higher [median: 9896.1 mg/L, interquartile range (IQR): 7898.3-12 634.6 mg/L] than those in their recorded (median: 975.6 mg/L, IQR: 136.9-4006.7 mg/L) counterparts. Besides ethanol, methanol also posed a health risk at each consumption level. The risk associated with exposure to OAAs was higher only in chronic heavy drinkers consuming unrecorded spirits. These findings reinforce the importance of action to address the risks associated with consumption of recorded and unrecorded spirits.