Autologous plasmin-assisted vitrectomy for stage 5 retinopathy of prematurity: A preliminary trial
Autologous plasmin-assisted vitrectomy for stage 5 retinopathy of prematurity: A preliminary trial
复制标题
DOI：
10.1016/j.ajo.2007.03.020
复制
发表时间：
2007-07-01
影响因子：
4.2
通讯作者：
Honda, Shigeru
中科院分区：
文献类型：
--
作者：
Tsukahara, Yasutomo;Honda, Shigeru
目得：评估自体纤溶酶（AP）辅助玻璃体切除术治疗5期早产儿视网膜病变（ROP）的疗效。设计：干预性病例系列。方法：治疗4名5期ROP儿童的6只连续眼睛。手术时患者的年龄从出生后5到8个月不等。4眼呈闭-闭构型，2眼呈开-开构型。在晶状体切除术和前增殖膜剥离后，将0.03至0.22国际单位（IU）的AP注入玻璃体腔。结果：增殖膜均成功去除，无医源性视网膜裂孔。6只眼（100%）后极部视网膜完全复位。随访11 ~ 14个月，无明显并发症发生。结论：玻璃体切除术中AP治疗5期ROP是有效的。
PURPOSE: To evaluate the efficacy of autologous plasmin (AP)-assisted vitrectomy for stage 5 retinopathy of prematurity (ROP).DESIGN: Interventional case series.METHODS: Six consecutive eyes of four children with stage 5 ROP were treated. The patients' ages at the surgery ranged from five to eight months after birth. Four eyes showed closed-closed configuration and two eyes showed open-open configuration. After lensectomy and dissection of the anterior proliferative membrane, 0.03 to 0.22 International Unit (IU) of AP was administrated into the vitreous cavity. After 15 to 30 minutes of incubation, the proliferative membrane was treated.RESULTS: The proliferative membrane was removed successfully without iatrogenic retinal break. Complete re, attachment of the posterior pole retina was achieved in all six eyes (100%). No obvious complication was observed in the follow,up period, which ranged from 11 to 14 months.CONCLUSIONS: These results suggest the benefit of AP in the vitrectomy for treatment of stage 5 ROP.