The mysterious role of the NLRP9 pyrin domain in inflammasome assembly.
The mysterious role of the NLRP9 pyrin domain in inflammasome assembly.
复制标题
DOI：
10.1002/1873-3468.13889
复制
发表时间：
2020-08
期刊：
影响因子：
3.5
通讯作者：
de Alba E
中科院分区：
文献类型：
--
作者：
de Alba E
促炎半胱天冬酶激活的分子基础是由一种被称为炎性体[1]的超分子蛋白平台的发现揭开的。自从近20年前在先天免疫方面取得科学突破以来，人们已经发现了对各种病原体和细胞损伤作出反应的不同类型的炎性小体。我们现在对炎性小体形成过程中涉及的蛋白质[3,4]、它们的结构和动态特征以及首选的相互作用伙伴[4 - 7]有了更好的了解。最近，我们已经能够确定炎症小体组装中关键的重要结构因素[8-11]。模式识别受体（炎性体传感器）[12]在存在特定病原体相关或危险相关的分子模式时被激活并寡聚。适配器蛋白ASC[5]通常伴随着激活的传感器，并通过其两个蛋白质相互作用的死亡结构域[pyrin结构域（PYD）和CARD]将寡聚传感器连接到procaspase-1分子。原aspase被募集到炎性小体平台上，通过邻近诱导的自动加工模型[13]促进其激活。活跃的半胱天冬酶可裂解促炎细胞因子（白介素-1β和白介素-18）和蛋白gasdermin D[14]。裂解后，后者导致裂解细胞通过焦亡死亡，并伴随活性细胞因子[14]的释放。炎症反应已经被触发。
The molecular foundation for the activation of proinflammatory caspases was unveiled by the discovery of a supramolecular protein platform known as the inflammasome [1]. Since this scientific breakthrough in innate immunity almost 20 years ago, different types of inflammasomes that respond to a variety of pathogens and cellular insults have been identified [2]. We now have a better understanding of the proteins involved in the formation of the inflammasome [3, 4], their structural and dynamic features, and preferred interaction partners [4–7]. More recently, we have been able to identify important structural factors that are key in inflammasome assembly [8–11].Pattern recognition receptors (inflammasome sensors)[12] become activated and oligomerize in the presence of specific pathogen-associated or danger-associated molecular patterns. The adaptor protein ASC [5] typically accompanies the activated sensor and, by means of its two protein-interacting death domains [pyrin domain (PYD) and CARD], connects the oligomerized sensor to procaspase-1 molecules. The recruitment of the procaspase into the inflammasome platform is assumed to facilitate its activation via the proximity-induced autoprocessing model [13]. The active caspase cleaves proinflammatory cytokines (interleukin-1β and interleukin-18) and the protein gasdermin D [14]. Upon cleavage, the latter leads to lytic cell death by pyroptosis and the concomitant release of the active cytokines [14]. The inflammatory response has been triggered.
登录
查看更多内容
影响因子：
--
作者：
Diaz-Parga P;de Alba E
通讯作者：
de Alba E
影响因子：
4.8
作者：
Oroz, Javier;Barrera-Vilarmau, Susana;de Alba, Eva
通讯作者：
de Alba, Eva
NLRP9B炎性体限制了肠上皮细胞中的轮状病毒感染。
影响因子：
64.8
作者：
Zhu S;Ding S;Wang P;Wei Z;Pan W;Palm NW;Yang Y;Yu H;Li HB;Wang G;Lei X;de Zoete MR;Zhao J;Zheng Y;Chen H;Zhao Y;Jurado KA;Feng N;Shan L;Kluger Y;Lu J;Abraham C;Fikrig E;Greenberg HB;Flavell RA
通讯作者：
Flavell RA
影响因子：
3.5
作者：
Ha, Hyun Ji;Park, Hyun Ho
通讯作者：
Park, Hyun Ho
影响因子：
16
作者：
Martinon, F;Burns, K;Tschopp, J
通讯作者：
Tschopp, J