Elevated red blood cell distribution width contributes to poor prognosis in patients undergoing resection for nonmetastatic rectal cancer.
Elevated red blood cell distribution width contributes to poor prognosis in patients undergoing resection for nonmetastatic rectal cancer.
复制标题
升高的红细胞分布宽度有助于接受非转移性直肠癌的患者预后不良。
DOI：
10.1097/md.0000000000009641
复制
发表时间：
2018-01
期刊：
影响因子：
1.6
通讯作者：
Wang Z
中科院分区：
文献类型：
--
作者：
Zhang X;Wu Q;Hu T;Gu C;Bi L;Wang Z
一些研究已经报道，红细胞分布宽度（RDW）升高与不同类型癌症的不良预后相关。本研究的目的是探讨RDW在非转移性直肠癌切除术患者中的预后作用。我们回顾性分析了2009年1月至2014年12月在我们机构接受非转移性直肠癌根治性切除术的625例连续患者的数据库。采用受试者工作特征曲线计算RDW的临界值。结果表明，高RDW-cv组患者的总生存期（OS）（P = 0.018）和无病生存期（P = 0.004）较低。 我们还观察到高RDW-sd组患者的OS显著较低（P = 0.033），而无病生存期（DFS）无显著差异（P = 0.179）。 在多变量分析中，我们发现RDW-cv升高与DFS较差相关（风险比[HR]= 1.56，P = 0.010），RDW-sd可预测OS较差（HR = 1.70，P = 0.009）。 我们证实RDW升高是非转移性直肠癌切除患者的独立预后因素。因此，对RDW值升高的非转移性直肠癌患者应加强干预或监测。
Several studies have reported that elevated red blood cell distribution width (RDW) was associated with the poor prognosis of different kinds of cancers. The aim of this study was to investigate the prognostic role of RDW in patients undergoing resection for nonmetastatic rectal cancer. We retrospectively reviewed a database of 625 consecutive patients who underwent curative resection for nonmetastatic rectal cancer at our institution from January 2009 to December 2014. The cutoff value of RDW was calculated by receiver-operating characteristic curve. The results demonstrated that patients in high RDW-cv group had a lower overall survival (OS) (P = .018) and disease-free survival (P = .004). We also observed that patients in high RDW-sd group were associated with significantly lower OS (P = .033), whereas the disease-free survival (DFS) was not significantly different (P = .179). In multivariate analysis, we found elevated RDW-cv was associated poor DFS (hazard ratio [HR] = 1.56, P = .010) and RDW-sd can predict a worse OS (HR = 1.70, P = .009). We confirmed that elevated RDW can be an independently prognostic factor in patients undergoing resection for nonmetastatic rectal cancer. So more intervention or surveillance might be paid to the patients with nonmetastatic rectal cancer and elevated RDW values in the future.