Mechanism of action of the sex steroid hormones (first of three parts).
Mechanism of action of the sex steroid hormones (first of three parts).
复制标题
性类固醇激素的作用机制（三部分中的第一部分）。
DOI：
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发表时间：
1976
影响因子：
158.5
通讯作者：
B. O’Malley
中科院分区：
文献类型：
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作者：
L. Chan;B. O’Malley
综述了性类固醇激素的作用机制。类固醇激素（雌激素、孕酮、雄激素）与靶组织的结合、激素受体复合物进入细胞核的易位、激素受体与染色质的相互作用以及性类固醇激素对染色质结构的影响是讨论的主要主题。一般来说，类固醇激素与细胞质受体结合后，激素受体复合物转移到靶细胞核。这就是荷尔蒙对基因活动施加影响的地方。一旦类固醇受体复合物进入细胞核，它就会与细胞核的脱氧核糖核酸-核蛋白复合物发生相互作用，这种复合物通常被称为染色质。类固醇激素可能通过这种相互作用对基因功能产生影响。目前激素作用的概念表明，类固醇激素的相互作用导致核糖核酸合成增加，随后导致蛋白质合成。
The mechanism of action of the sex steroid hormones is reviewed. Bi nding of steroid hormone (estrogen, progesterone, androgen) by target tissue, translocation of the hormone-receptor complex into the nucleus, hormone-receptor interactions with chromatin, and effects of the sex steroid hormones on chromatin structure are the main topics of discussio n. In general, after the steroid hormone is bound to a cytoplasmic receptor the transfer of the hormone-receptor complex into the target cell nucleus takes place. This is where the hormone exerts its influence on gene activity. Once the steroid-receptor complex moves into the nucleus it undergoes an interaction with the deoxyribonucleic acid-nucleoprotein complex of the cell nucleus that is often referred to as chromatin. The steroid hormone may exert its influence on gene function through this interaction. Current concepts of hormone action suggest that interaction of steroid hormones leads to increased ribonucleic acid synthesis and subsequently to protein synthesis.