Effectiveness, medication patterns, and adverse events of traditional chinese herbal patches for osteoarthritis: a systematic review.
Effectiveness, medication patterns, and adverse events of traditional chinese herbal patches for osteoarthritis: a systematic review.
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中药贴剂治疗骨关节炎的疗效、用药模式和不良反应：系统评价
DOI：
10.1155/2014/343176
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Zhan H
中科院分区：
文献类型：
--
作者：
Wang X;Wei S;Liu T;Pang J;Gao N;Ding D;Duan T;Cao Y;Zheng Y;Zhan H
客观的。本研究的目的是系统评估传统中药贴剂（TCHP）治疗骨关节炎（OA）是否有效和安全的证据，并分析其用药模式。方法。使用 1979 年 1 月至 2013 年 7 月期间所有可能的医学主题标题 (MeSH) 和关键词进行系统文献检索。随机对照试验 (RCT) 和观察性研究均包括在内。使用平均差 (MD) 或相对风险 (RR) 和 95% 置信区间 (CI) 以及荟萃分析来分析估计效果。结果。已鉴定出 86 种 TCHP。大部分质量较低的随机对照试验和对照临床试验 (CCT) 有利于 TCHP 缓解局部疼痛和功能障碍。与双氯芬酸软膏相比，TCHP 对总体有效率有显着影响（RR = 0.50；95% CI (0.29, 0.87)）。配方成分以“小活络丹”和“独活寄生汤”为主。 3-4周的随访后发现了10种不良事件（AE），主要包括瘙痒和/或局部皮疹。结论。 TCHPs 在提高 OA 的全球有效率方面有一定的证据；然而，需要更严格的研究来支持它们的使用。
Objective. The aim of this study is to systematically evaluate the evidence whether traditional Chinese herbal patches (TCHPs) for osteoarthritis (OA) are effective and safe and analyze their medication patterns. Methods. A systematic literature search was performed using all the possible Medical Subject Headings (MeSH) and keywords from January 1979 to July 2013. Both randomized controlled trials (RCTs) and observational studies were included. Estimated effects were analyzed using mean difference (MD) or relative risk (RR) with 95% confidence intervals (CI) and meta-analysis. Results. 86 kinds of TCHPs were identified. RCTs and controlled clinical trials (CCTs) which were mostly of low quality favored TCHPs for local pain and dysfunction relief. TCHPs, compared with diclofenac ointment, had significant effects on global effectiveness rate (RR = 0.50; 95% CI (0.29, 0.87)). Components of formulae were mainly based on the compounds “Xiao Huo Luo Dan” (Minor collateral-freeing pill) and “Du Huo Ji Sheng Tang” (Angelicae Pubescentis and Loranthi decoction). Ten kinds of adverse events (AEs), mainly consisting of itching and/or local skin rashes, were identified after 3-4 weeks of follow-up. Conclusions. TCHPs have certain evidence in improving global effectiveness rate for OA; however, more rigorous studies are warranted to support their use.