Irx1 and Irx2 expression in early lung development
Irx1 and Irx2 expression in early lung development
复制标题
DOI：
10.1016/s0925-4773(01)00412-9
复制
发表时间：
2001-08-01
影响因子：
2.6
通讯作者：
Gruss, P
中科院分区：
文献类型：
--
作者：
Becker, MB;Zülch, A;Gruss, P
我们描述了对小鼠irx1和irx2基因的肺表达的比较分析。在胚胎第8.5天(E8.5)，Irx1和Irx2的表达开始在前肠区域，在那里将形成喉-气管沟。在腺体发育过程中，该基因在肺上皮细胞中的表达显著。它在管状期结束时下降。我们进一步将Irx1和Irx2的表达结构域与Gli1、2、3和Mash1进行了比较。它们在黑腹果蝇中的同系物被认为是易洛魁复合体的调节伙伴。Irx和Gli基因在发育中的肺中同时共表达。它们的转录本并不位于相同的细胞中，而是在间质或上皮结构中彼此相邻。目前认为肺发育受间充质/上皮细胞相互作用的调节。(C)2001爱思唯尔爱尔兰科学有限公司。保留所有权利。
We describe a comparative lung expression analysis of the murine Irx1 and Irx2 genes. At embryonic day 8.5 (E8.5), the Irx1 and Irx2 expression starts in the foregut region, where the laryngo-tracheal groove will form. The expression is prominent in the lung epithelium during glandular development. It declines at the end of the canalicular phase. We further compare the Irx1 and Irx2 expression domains to Gli1, 2, 3 and Mash1. Their homologues in Drosophila melanogaster are known as regulative partners of the iroquois complex. The Irx and Gli genes are coexpressed in the developing lungs at the same time. Their transcripts are not localised in the same cells but adjacent to each other in either mesenchymal or epithelial structures. It is thought that the lung development is regulated by the mesenchymal/epithelial interactions. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.