Effect of antibacterial home cleaning and handwashing products on infectious disease symptoms - A randomized, double-blind trial
Effect of antibacterial home cleaning and handwashing products on infectious disease symptoms - A randomized, double-blind trial
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DOI：
10.7326/0003-4819-140-5-200403020-00007
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发表时间：
2004-03-02
影响因子：
39.2
通讯作者：
Della-Latta, P
中科院分区：
文献类型：
--
作者：
Larson, EL;Lin, SX;Della-Latta, P
背景：尽管含有抗菌成分的清洁和个人卫生用品在家庭中广泛使用，但它们对传染病症状发生率的影响尚未得到研究。目的：评价消费者抗菌清洁洗手产品对家庭传染病症状发生的影响。设计：随机、双盲临床试验。环境：纽约曼哈顿北部内城社区。参与者：238个主要是西班牙裔家庭（1178人），其中至少包括一名学龄前儿童。干预措施：家庭被随机分配使用抗菌或非抗菌产品进行一般清洁、洗衣和洗手。所有的产品都是市售的，但包装是不透明的，产品是免费提供给参与者的。测量方法：通过每周电话、每月家访和季度访谈监测卫生习惯和传染病症状，为期48周。结果：症状以呼吸系统为主：在26.2%（717 / 2736）、23.3%（640 / 2737）和10.2%（278 / 2737）的家庭月期间，分别有1名或多名家庭成员出现流鼻涕、咳嗽或喉咙痛。2737例中有301例出现发热，2.2%（61例）出现呕吐，2.5%（69例）出现腹泻，0.77%（21例）出现疖疮或结膜炎。干预组与对照组在任何症状（所有未调整和调整的相对风险均为1.0）或症状数量（总发病率密度比为0.96 [95% CI， 0.82至1.12]）方面均无显著差异。结论：测试的抗菌产品并没有降低包括基本健康的人在内的家庭中病毒性传染病症状的风险。这并不排除这些产品对减少家中细菌性疾病症状的潜在贡献。
Background: Despite the widespread household use of cleaning and personal hygiene products containing antibacterial ingredients, their effects on the incidence of infectious disease symptoms have not been studied.Objective: To evaluate the effect of antibacterial cleaning and handwashing products for consumers on the occurrence of infectious disease symptoms in households.Design: Randomized, double-blind clinical trial.Setting: Northern Manhattan inner-city neighborhood, New York.Participants: 238 primarily Hispanic households (1178 persons) that included at least one preschool-age child.Interventions: Households were randomly assigned to use either antibacterial or nonantibacterial products for general cleaning, laundry, and handwashing. All products were commercially available, but the packaging was blinded and the products were provided free to participants.Measurements: Hygiene practices and infectious disease symptoms were monitored by weekly telephone calls, monthly home visits, and quarterly interviews for 48 weeks.Results: Symptoms were primarily respiratory: During 26.2% (717 of 2736) of household-months, 23.3% (640 of 2737) of household-months, and 10.2% (278 of 2737) of household-months, one or more members of the household had a runny nose, cough, or sore throat, respectively. Fever was present during 11% (301 of 2737) of household-months, vomiting was present in 2.2% (61 of 2737), diarrhea was present in 2.5% (69 of 2737), and boils or conjunctivitis were present in 0.77% (21 of 2737). Differences between intervention and control groups were not significant for any symptoms (all unadjusted and adjusted relative risks included 1.0) or for numbers of symptoms (overall incidence density ratio, 0.96 [95% CI, 0.82 to 1.12]).Conclusions: The tested antibacterial products did not reduce the risk for symptoms of viral infectious diseases in households that included essentially healthy persons. This does not preclude the potential contribution of these products to reducing symptoms of bacterial diseases in the home.