Retinoic aid increases arrestin mRNA levels in the mouse retina.
Retinoic aid increases arrestin mRNA levels in the mouse retina.
复制标题
视黄酸有助于增加小鼠视网膜中抑制蛋白 mRNA 的水平。
DOI：
10.1096/fasebj.11.4.9068616
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Dräger,UC
中科院分区：
文献类型：
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作者：
Wagner,E;McCaffery,P;Mey,J;Farhangfar,F;Applebury,ML;Dräger,UC
抑制蛋白在视觉转导级联反应的终止中发挥作用，是mRNA水平因光而增加的几种感光蛋白之一。视黄酸是光感受器信号传导的副产物，也是激素转录控制的有效调节剂，是调节arrestin mRNA水平的候选物之一。在这里，我们表明，视黄酸，intraperitoneal注射到黑暗适应小鼠，增加arrestin mRNA水平和模仿光的影响。注射1 μmol维甲酸可使arrestin mRNA水平最大程度增加。mRNA水平在注射后3 h达到最大值，此后缓慢下降。观察结果表明，视黄酸可能介导光产生的抑制蛋白mRNA的增加。瓦格纳，McCaffery，P.，梅，J.，Farhangfar，F.，Applebury，M. L.，德拉格大学C.维甲酸增加小鼠视网膜中抑制蛋白mRNA水平。FASEB J.11，271 - 275（1997）
Arrestin, which plays a role in the termination of the visual transduction cascade, is one of several photoreceptor proteins whose mRNA levels are increased by light. Retinoic acid, a by‐product of photoreceptor signaling and a potent modulator of hormonal transcription control, is one candidate for regulating the arrestin mRNA levels. Here we show that retinoic acid, injected intraperi‐toneally into dark‐adapted mice, increases the arrestin mRNA levels and mimics the effect of light. Injection of 1 μmol of retinoic acid produces a maximal increase in arrestin mRNA levels. The mRNA level reaches a maximum 3 h after injection and slowly declines thereafter. The observations suggest that retinoic acid may mediate the increase in arrestin mRNA produced by light.—Wagner, E., McCaffery, P., Mey, J., Farhangfar, F., Applebury, M. L., Dräger, U. C. Retinoic aid increases arrestin mRNA levels in the mouse retina.FASEB J.11, 271‐275 (1997)