The relation of obesity throughout life to carotid intima-media thickness in adulthood: the Bogalusa Heart Study
The relation of obesity throughout life to carotid intima-media thickness in adulthood: the Bogalusa Heart Study
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DOI：
10.1038/sj.ijo.0802515
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发表时间：
2004-01-01
影响因子：
4.9
通讯作者：
Berenson, GS
中科院分区：
文献类型：
--
作者：
Freedman, DS;Dietz, WH;Berenson, GS
目的：虽然肥胖儿童在以后的生活中患冠心病的风险增加，但尚不清楚这种联系是否是儿童肥胖持续到成年的结果。我们研究了肥胖在不同年龄段的颈动脉内膜中层厚度（IMT）在35岁的关系。设计：前IMT的测定由B型超声，受试者（203名男性，310名女性），平均有6个测量体重指数（BMI）和三头肌皮褶厚度（TSF）之间的4和35岁。采用纵向资料的混合回归模型评估这些特征与成人IMT的关系。结果：总体而言，成人IMT与BMI和TSF水平均相关（P
OBJECTIVE: Although obese children are at increased risk for coronary heart disease in later life, it is not clear if this association results from the persistence of childhood obesity into adulthood. We examined the relation of adiposity at various ages to the carotid intima-media thickness (IMT) at age 35 y.DESIGN: Prior to the determination of IMT by B-mode ultrasound, subjects ( 203 men, 310 women) had, on average, six measurements of body mass index (BMI) and triceps skinfold thickness (TSF) between the ages of 4 and 35 y. Mixed regression models for longitudinal data were used to assess the relation of these characteristics to adult IMT.RESULTS: Overall, adult IMT was associated with levels of both BMI and TSF (P