Prognostic roles of Notch receptor mRNA expression in human ovarian cancer.
Prognostic roles of Notch receptor mRNA expression in human ovarian cancer.
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Notch受体mRNA表达在人卵巢癌中的预后作用
DOI：
10.18632/oncotarget.16387
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发表时间：
2017-05-16
期刊：
影响因子：
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通讯作者：
Yu S
中科院分区：
文献类型：
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作者：
Chen C;Wang X;Huang S;Wang L;Han L;Yu S
Notch信号通路的异常激活与高级别卵巢癌的发生、发展密切相关。然而，Notch信号通路在卵巢癌患者中的预测和预后价值仍不清楚。我们利用“Kaplan-Meier曲线”（KM曲线）背景数据库来访问卵巢癌患者中四种Notch受体mRNA表达的预后值，包括总生存期（OS）、无进展生存期（PFS）以及进展后生存期（PPS）。Notch 1 mRNA高表达与所有卵巢癌患者的OS、PFS和PPS均无相关性，但与TP 53野生型患者的PFS差和TP 53突变型患者的PFS好相关。Notch 2 mRNA高表达与所有卵巢癌患者的不良PFS显著相关，尤其是在II级患者中。Notch 3 mRNA高表达与所有卵巢癌患者的最佳PFS显著相关。Notch 4 mRNA高表达与卵巢癌患者的OS显著相关，但与PFS和PPS无关。结果强烈支持四种Notch受体mRNA表达在卵巢癌患者中具有不同的预后价值。
Aberrant activation of Notch signaling pathway has been correlated with high grade ovarian carcinoma and carcinogenesis. However, the predictive and prognostic values of Notch signaling pathway in ovarian cancer patients remains unclear. We utilize “The Kaplan-Meier plotter” (KM plotter) background database to access the prognostic values including overall survival (OS), progression-free survival (PFS), as well as post-progression survival (PPS) of four Notch receptor mRNA expression in ovarian cancer patients. Notch1 mRNA high expression was not correlated with OS, PFS and PPS for all ovarian cancer patients, but significantly correlated with poor PFS in TP53 wild type and favorite PFS in TP53 mutation type ovarian cancer patients. Notch2 mRNA high expression was significantly correlated with poor PFS for all ovarian cancer patients, especially in grade II patients. Notch3 mRNA high expression was significantly correlated with favorite PFS for all ovarian cancer patients. Notch4 mRNA high expression was significantly correlated with favorite OS, but not PFS and PPS for all ovarian cancer patients. The results strongly support that there are distinct prognostic values of four Notch receptor mRNA expression in ovarian cancer patients.