INCREASED PRODUCTION OF INTERFERON GAMMA AND TUMOR NECROSIS FACTOR PRECEDES CLINICAL MANIFESTATION IN MULTIPLE-SCLEROSIS - DO CYTOKINES TRIGGER OFF EXACERBATIONS
INCREASED PRODUCTION OF INTERFERON GAMMA AND TUMOR NECROSIS FACTOR PRECEDES CLINICAL MANIFESTATION IN MULTIPLE-SCLEROSIS - DO CYTOKINES TRIGGER OFF EXACERBATIONS
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DOI：
10.1111/j.1600-0404.1988.tb03663.x
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发表时间：
1988-10-01
影响因子：
3.5
通讯作者：
WIETZERBIN, J
中科院分区：
文献类型：
--
作者：
BECK, J;RONDOT, P;WIETZERBIN, J
我们对20例多发性硬化症（MS）患者和一名健康对照组进行了干扰素（IFN）和肿瘤坏死因子（TNF）的纵向研究。我们建立了个体特征，每个个体的结果都很稳定，无论是健康供体还是缓解期患者。然而，在恶化之前，我们发现IFN-γ增加。并且TNF产生先于临床症状最多2周。在良性病例中，增加迅速消失，甚至在症状出现之前，而我们发现后遗症时，增加持续数周。在慢性进展性患者中，我们经常发现干预性增加。可能是IFN-γ。和TNF在非常早期的阶段触发恶化，并且这些细胞因子也可能在维持慢性进行性和无效形式的疾病中起作用。
We have carried out a longitudinal study of interferon (IFN) and tumor necrosis factor (TNF) using a whole-blood mitogen stimulation assay in 20 multiple sclerosis (MS) patients and in a healthy control group. We set up individual profiles and the results were quite constant for each individual, both in healthy donors and in the patients in remission. Before exacerbations, however, we found an increase of IFN-.gamma. and TNF production preceding clinical symptoms by a maximum of 2 weeks. In benign cases, the increase disappeared rapidly, even before the appearance of symptoms, whereas we found sequelae whenever the increase persisted during weeks. In chronic progressive patients, we frequently found intervening increases. It may be that IFN-.gamma. and TNF trigger off exacerbations at a very early stage and that these cytokines may also play a role in maintaining disease in chronic progressive and invalidating forms.