Antioxidant properties of jujube honey and its protective effects against chronic alcohol-induced liver damage in mice
Antioxidant properties of jujube honey and its protective effects against chronic alcohol-induced liver damage in mice
复制标题
枣蜜的抗氧化特性及其对小鼠慢性酒精性肝损伤的保护作用
DOI：
10.1039/c3fo60623f
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发表时间：
2014-05-01
期刊：
影响因子：
6.1
通讯作者：
Feng, Fan
中科院分区：
文献类型：
--
作者：
Cheng, Ni;Du, Bing;Feng, Fan
枣蜜是中国消费最广泛的蜂蜜之一，其抗氧化潜力尚未完全确定。本研究分析了来自中国6个地理来源的枣蜜的单个酚酸、总酚含量以及对小鼠慢性酒精相关性肝病的抗氧化作用。结果表明，山西临县枣蜜中酚类物质含量较高，具有DPPH抗氧化活性、铁离子还原性抗氧化能力（FRAP）和抗DNA损伤作用。山西临县枣蜜治疗12周可明显抑制血清脂蛋白氧化，降低酒精中毒对天门冬氨酸氨基转移酶（AST）和丙氨酸氨基转移酶（ALT）的影响。抑制8-羟基-2-脱氧鸟苷（8-OHdG）的生成，降低丙二醛（MDA）含量，提高谷胱甘肽过氧化物酶（GSH-Px）活性。该研究表明，枣蜂蜜具有有效的抗氧化活性，并对慢性酒精中毒相关的肝脏疾病具有显着的保护作用。其保护作用归因于其抗氧化机制和抑制脂质的氧化降解。
The antioxidant potential of jujube honey, one of the most widely consumed honeys in China, has never been determined fully. In this study, jujube honey from six geographical origins in China was analyzed for individual phenolic acid, total phenolic content, and the antioxidant effect in chronic alcohol-related hepatic disease in mice. The results showed that jujube honey from Linxian of Shanxi province contained higher phenol levels, exhibited DPPH antioxidant activity, ferric ion reducing antioxidant power (FRAP) and protective effects against DNA damage. Treatment with jujube honey (Shanxi Linxian) for 12 weeks significantly inhibited serum lipoprotein oxidation, reduced the impact of alcoholism on aspartate aminotransferase (AST) and alanine aminotransferase (ALT). It also inhibited the generation of 8-hydroxy-2-deoxyguanosine (8-OHdG), lowered the levels of malondialdehyde (MDA) and increased the activity of hepatic glutathione peroxidase (GSH-Px). The study indicates that jujube honey exerts potent antioxidant activity and significant protection in hepatic disorders associated with chronic alcoholism. The protective effect is attributed to its antioxidant mechanisms and inhibition of oxidative degradation of lipids.