The relationship between the locomotor response to a novel environment and behavioral disinhibition in rats
The relationship between the locomotor response to a novel environment and behavioral disinhibition in rats
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DOI：
10.1016/j.drugalcdep.2007.06.012
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发表时间：
2008-01-01
影响因子：
4.2
通讯作者：
Cunningham, Kathryn A.
中科院分区：
文献类型：
--
作者：
Stoffel, Erin C.;Cunningham, Kathryn A.
行为去抑制是冲动的一个组成部分，与可卡因滥用和依赖有关。为了研究行为去抑制和可卡因使用障碍的脆弱性之间的关系，我们采用了高反应（HR）/低反应（LR）啮齿动物模型，在该模型中，表现出高水平的活动，以响应新的环境的大鼠对精神兴奋剂的影响更敏感。在实验1中，性能下的差异强化低速率（DRL）计划被用来作为衡量FIR和LR大鼠的行为去抑制。在DRL 20-和35-s时间表上，HR大鼠相对于LR大鼠表现出更多的行为去抑制。实验二根据DRL 20-s表现将大鼠分为高去抑制（HD）组和低去抑制（LD）组，然后用可卡因进行攻击。表征为HD和LD的大鼠分别与表征为FIR和LR（实验1）的大鼠具有相似的DRL 20-s性能，但它们对可卡因的反应没有差异。本研究的结果表明，HR表型也可能具有更大的行为去抑制的特点，DRL任务是一个合适的动物模型来研究行为去抑制的作用，在可卡因的行为效应的脆弱性。(C)2007年由Elsevier爱尔兰有限公司出版。
Behavioral disinhibition, a component of impulsivity, has been associated with cocaine abuse and dependence. To examine the relationship between behavioral disinhibition and vulnerability to cocaine use disorders, we employed the high responder (HR)/low responder (LR) rodent model, in which rats that exhibit high levels of activity in response to a novel environment are more sensitive to the effects of psychostimulants. In Experiment 1, performance under a differential reinforcement of low-rate (DRL) schedule was used as a measure of behavioral disinhibition in FIR and LR rats. The HR rats displayed more behavioral disinhibition relative to LR rats on the DRL 20- and 35-s schedules. In Experiment 2, rats were divided into groups with high disinhibition (HD) and low disinhibition (LD) based on DRL 20-s performance, then challenged with cocaine. Rats characterized as HD and LD had similar DRL 20-s performance to rats characterized as FIR and LR (Experiment 1), respectively, but did not differ in their response to cocaine. The results of this study suggest that the HR phenotype may also be characterized by greater behavioral disinhibition, and that the DRL task is a suitable animal model to investigate the role of behavioral disinhibition in vulnerability to the behavioral effects of cocaine. (C) 2007 Published by Elsevier Ireland Ltd.