EEG coherency .1. Statistics, reference electrode, volume conduction, Laplacians, cortical imaging, and interpretation at multiple scales
EEG coherency .1. Statistics, reference electrode, volume conduction, Laplacians, cortical imaging, and interpretation at multiple scales
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DOI：
10.1016/s0013-4694(97)00066-7
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发表时间：
1997-11-01
期刊：
影响因子：
--
通讯作者：
Cadusch, PJ
中科院分区：
文献类型：
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作者：
Nunez, PL;Srinivasan, R;Cadusch, PJ
在EEG相干性研究中影响实验设计和生理解释的几个方法学问题被考虑，包括参考电极和体积传导对错误相干性估计的贡献。一个新的措施，“减少相干性”，被引入作为测量的相干性和预期的相干性之间的差异，从不相关的新皮层源，基于模拟和分析统计研究与体积导体模型。减少相干性的概念被证明是在半定量协议与实验EEG数据。体积传导的统计置信区间的相干性估计的影响进行了讨论。传统的参考，平均参考，双极，拉普拉斯，和皮质图像相干性被证明是部分独立的措施，在不同的空间尺度的新皮层动态功能，由于每种方法的独特的空间过滤颅内源活动。(C)1997 Elsevier Science爱尔兰有限公司
Several methodological issues which impact experimental design and physiological interpretations in EEG coherence studies are considered, including reference electrode and volume conduction contributions to erroneous coherence estimates. A new measure, 'reduced coherency', is introduced as the difference between measured coherency and the coherency expected from uncorrelated neocortical sources, based on simulations and analytic-statistical studies with a volume conductor model. The concept of reduced coherency is shown to be in semi-quantitative agreement with experimental EEG data. The impact of volume conduction on statistical confidence intervals for coherence estimates is discussed. Conventional reference, average reference, bipolar, Laplacian, and cortical image coherencies are shown to be partly independent measures of neocortical dynamic function at different spatial scales, due to each method's unique spatial filtering of intracranial source activity. (C) 1997 Elsevier Science Ireland Ltd.