Effectiveness of live-attenuated Japanese encephalitis vaccine (SA14-14-2): A case-control study
Effectiveness of live-attenuated Japanese encephalitis vaccine (SA14-14-2): A case-control study
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DOI：
10.1016/s0140-6736(96)91075-2
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发表时间：
1996-06-08
期刊：
影响因子：
168.9
通讯作者：
Halstead, SB
中科院分区：
文献类型：
--
作者：
Hennessy, S;Liu, ZL;Halstead, SB
背景日本脑炎是包括印度次大陆在内的整个亚洲地区死亡和致残的主要原因。尽管有一种有效的乙脑疫苗可用，但由于疫苗的成本，数亿易感人群仍未接种疫苗。1988年，一种廉价的减毒活疫苗(SA14-14-2)在中国获得许可。方法在四川省农村进行病例对照研究，对56例经血清学确诊的急性乙型脑炎住院患儿中国进行疫苗免疫效果检测。确定了1299名与村庄匹配和年龄匹配的对照组，并从先前存在的书面记录中获得了疫苗接种历史。结果单剂有效率为80%(95%可信区间44~93%)，两剂有效率为97.5%(86%~99.6%)。对多个潜在混杂因素的控制并没有改变这些结果。解释我们得出结论，间隔1年接种两剂乙脑减毒活疫苗在预防临床重要疾病方面是有效的，需要进行后续研究以确保该疫苗的安全性。
Background Japanese encephalitis is a major cause of death and disability throughout Asia, including the Indian subcontinent. Although an effective vaccine for Japanese encephalitis is available, hundreds of millions of susceptible individuals remain unimmunised because of the vaccine's cost. In 1988, an inexpensive live-attenuated vaccine (SA14-14-2) was licensed in China. We have measured the effectiveness of this vaccine,Methods In a case-control study in rural Sichuan Province, to China, the 56 cases consisted of children admitted to hospital with acute Japanese encephalitis, and were confirmed serologically. 1299 village-matched and age-matched controls were identified, and vaccination histories obtained from pre-existing written records. Findings The effectiveness of one dose was 80% (95% CI 44 to 93%); that of two doses was 97.5% (86 to 99.6%). Controlling for multiple potential confounders did not alter these results.Interpretation We conclude that a regimen of two doses of live-attenuated Japanese encephalitis vaccine, administered 1 year apart, is effective in the prevention of clinically important disease, Subsequent study is needed to assure the safety of this vaccine.