Antibiogram of E. coli serotypes isolated from children aged under five with acute diarrhea in Bahir Dar town
Antibiogram of E. coli serotypes isolated from children aged under five with acute diarrhea in Bahir Dar town
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DOI：
10.4314/ahs.v15i2.45
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发表时间：
2015-01-01
影响因子：
1
通讯作者：
Adal, Melaku
中科院分区：
文献类型：
--
作者：
Adugna, Ayrikim;Kibret, Mulugeta;Adal, Melaku
背景：腹泻病及其并发症仍然是儿童发病和死亡的主要原因。腹泻病原大肠杆菌的流行率和抗菌谱因地区不同而不同，甚至在同一地理区域的国家内部也不同。目的：确定五岁以下儿童大肠杆菌的血清型和抗菌药物敏感性。方法：对2011年12月至2012年2月的422名腹泻儿童进行横断面研究。大肠杆菌的鉴定和抗菌药物敏感性测试按照标准进行结果：大肠杆菌总体分离率为48.3%。聚2血清群、聚3血清群、聚4血清群和大肠杆菌O157:H7分别占分离株的80个（39.2%）、40个（19.6%）、25个（12.3%）和59个（28.9%）。 Poly 2 血清群属于肠致病性大肠杆菌，是最常见的分离血清型。大肠杆菌对氨苄青霉素（86.8%）、四环素（76%）和复方新诺明（76%）表现出高水平的抗菌药物耐药性。据记录，对环丙沙星 (6.9%) 和诺氟沙星 (9.3%) 的耐药性水平较低。结论：致腹泻性大肠杆菌的高患病率加上令人震惊的抗菌药物耐药性是一个严重的公共卫生问题。建议定期测定抗菌谱并进行公众教育。
Background: Diarrheal disease and its complications remain a major cause of morbidity and mortality in children. The prevalence and antibiogram of E. coli as causative agents of diarrhea vary from region to region, and even within countries in the same geographical area.Objectives: To determine the serotype and antimicrobial susceptibility of E. coli in children under-five years of age.Methods: A cross-sectional study was conducted among 422 children with diarrhea from December 2011 to February 2012. Identification of E. coli and antimicrobial susceptibility testing were done following standard procedures.Results: The overall isolation rate of E. coli was 48.3%. Poly 2 sero-groups, poly 3 sero-groups, poly 4 sero-groups and E. coli O157:H7 accounted for 80 (39.2%), 40 (19.6%), 25 (12.3%), and 59 (28.9%) of the isolates, respectively. Poly 2 sero-groups, constituting isolates belonging to enteropathogenic E. coli were the most commonly isolated serotypes. E. coli exhibited high levels of antimicrobial resistance to ampicillin (86.8%), tetracycline (76%) and cotrimoxazole (76%). Low levels of resistance to ciprofloxacin (6.9%) and norfloxacin (9.3%) were documented.Conclusion: High prevalence of diarrheagenic E. coli compounded by alarming antimicrobial resistances is a serious public health problem. Regular determination of antibiogram and public education are recommended.