Chiral tubule self-assembly from an achiral diynoic lipid
Chiral tubule self-assembly from an achiral diynoic lipid
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DOI：
10.1073/pnas.0030051100
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发表时间：
2003-03-18
影响因子：
11.1
通讯作者：
Thomas, BN
中科院分区：
文献类型：
--
作者：
Pakhomov, S;Hammer, RP;Thomas, BN
具有μ m级手性亚结构的小管由形成小管的二炔酸磷脂酰胆碱的非手性异构体1，2-双（10，1,2-tricosadiynoyl）sn-甘油-3-磷酸胆碱[DC（8，9）PC]自组装，表明分子手性对小管形成不是必需的。CD光谱表明，这些结构的螺旋旋向性反而起源于自发的合作手性破坏过程。我们的结论是，手性的手性断裂必须起源于不寻常的功能共同的手性和非手性管形成分子，二炔集中在他们的烃尾巴。
Tubules possessing mum-scale chiral substructure self-assemble from an achiral isomer of the tubule-forming diynoic phosphatidylcholine, 1,2-bis(10,12-tricosadiynoyl)sn-glycero-3-phosphocholine [DC(8,9)PC], showing that molecular chirality is not essential for tubule formation. CD spectroscopy shows that these structures' helical sense of handedness instead originates in a spontaneous cooperative chiral symmetry-breaking process. We conclude that the chiral symmetry-breaking must originate in the unusual feature common to the chiral and achiral tubule-forming molecules, the diynes centered in their hydrocarbon tails.