Factors affecting the test-retest variability of Heidelberg retina tomograph and Heidelberg retina tomograph II measurements
Factors affecting the test-retest variability of Heidelberg retina tomograph and Heidelberg retina tomograph II measurements
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DOI：
10.1136/bjo.2005.067298
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发表时间：
2005-11-01
影响因子：
4.1
通讯作者：
Garway-Heath, DF
中科院分区：
文献类型：
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作者：
Strouthidis, NG;White, ET;Garway-Heath, DF
目的：评估使用海德堡视网膜断层扫描仪 (HRT) 和海德堡视网膜断层断层扫描仪 (HRT-II) 进行的立体测量参数测量的重测变异性，并确定哪些参数可使用这两种设备提供最可重复和最可靠的测量。对影响该参数测量重复性的因素进行了调查。方法：招募 43 名高眼压患者和 31 名青光眼受试者参加重测研究。每个受试者的一只眼睛在 6 周内分别由两名观察者两次接受 HRT 和 HRT-II 成像。镜片分级通过 LOCS III 分级和 Scheimpflug 相机生成的密度图分析进行。结果：边缘面积 (RA) 和平均视杯深度测量值变化最小。测试间参考高度差和图像质量都与测试间 RA 差异有很强的相关性 (R-2 >0.5，p< 0.0001)，并且共同造成了 70% 的 RA 测量变异。图像质量受到镜片不透明度、柱面误差和年龄的影响。测试间 RA 测量差异与观察者或访视间隔无关。结论：RA 代表了监测青光眼进展的适当措施。参考高度差和图像质量是影响 RA 测量变异性的最大因素。解决这些因素的图像分析策略可能会减少重测变异性。
Aims: To evaluate the test-retest variability of stereometric parameter measurements made with the Heidelberg retina tomograph (HRT) and Heidelberg retina tomograph-II (HRT-II), and to establish which parameter(s) provided the most repeatable and reliable measurements with both devices. An investigation into the factors affecting the repeatability of the measurements of this parameter( s) was conducted.Methods: 43 ocular hypertensive and 31 glaucoma subjects were recruited to a test-retest study. One eye from each subject underwent HRT and HRT-II imaging by two observers on each of two occasions within 6 weeks of each other. Lens grading was carried out by LOCS III grading and Scheimpflug camera generated densitogram analysis.Results: Rim area ( RA) and mean cup depth measurements were found to be least variable. Both inter-test reference height difference and image quality had a strong relation (R-2 >0.5, p< 0.0001) with inter-test RA difference and, together, are responsible for 70% of RA measurement variability. Image quality was influenced by lens opacity, cylindrical error, and age. Inter-test RA measurement differences were unrelated to the observer or visit interval.Conclusions: RA represents an appropriate measure for monitoring glaucomatous progression. Reference height difference and image quality were the factors that most influenced RA measurement variability. Image analysis strategies that address these factors may reduce test-retest variability.