RNA Back to the Spotlight.
RNA Back to the Spotlight.
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RNA 回到聚光灯下。
DOI：
10.1016/j.jsb.2020.107555
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发表时间：
2020
影响因子：
3
通讯作者：
Schlick,T
中科院分区：
文献类型：
--
作者：
Schlick,T
当我们现在面对因冠状病毒大流行而改变的生活时，回忆起前几天的科学会议几乎是不可想象的。特别是，共享一个小教室，俯瞰美丽的特柳赖德周围环境，或者在宁静的山脉中徒步旅行，似乎远离了过去 100 天的隔离生活和关闭的实验室和街道。然而，随着 Covid-19 成为每个人关注的焦点，我们尊敬的课题 RNA 及其带来的建模挑战从未像现在这样重要。正如《结构生物学杂志》的本期特刊所表明的那样，RNA 结构分析、预测和设计方面的挑战使实验和理论科学家保持着积极的参与和创造力。本集合中的文章是由 Anna Pyle 和我于 2014 年发起的关于 RNA 建模和设计挑战的特柳赖德科学研究会议 (TSRC) 研讨会的成果，除今年外每两年重复一次。这是我们会议之后的第三期特刊，其中特刊出现在 2016 年的《分子生物学杂志》和 2017 年的《生物物理学杂志》上（Pyle 和 Schlick，2016 年；Schlick 和 Pyle，2017 年）。我们在研讨会和这个特别系列中讨论的这些 RNA 挑战产生了许多创新的多学科方法来分析、预测、模拟和设计 RNA 分子。大RNA，例如covid-19病毒的基因组，带来了特殊的挑战。毫无疑问，在不久的将来，我们将会见证更多这方面的创新。我期待在未来的 RNA 面对面会议上讨论这些进展。
As we deal now with our upended lives due to the coronavirus pandemic, it is almost unimaginable to recall scientific meetings of prior days. In particular, sharing a small classroom overlooking gorgeous Telluride surroundings, or hiking in peaceful mountains seem like worlds away from the quarantine life and shut down labs and streets that have been the life here for the past 100 days. Yet our esteemed subject—RNA—and the modeling challenges it brings have never been more important as now, with Covid-19 on everyone’s mind. As this special issue of the Journal of Structural Biology illustrates, challenges in RNA structure analysis, prediction, and design keep experimental and theoretical scientists engaged and inventive. The articles in this collection are an outcome of the Telluride Science Research Conference (TSRC) workshop on Challenges in RNA Modeling and Design started by Anna Pyle and me in 2014, and repeated every two years except this year. This is the third special issue that followed our meetings, with special issues appearing in the Journal of Molecular Biology in 2016 and in Biophysical Journal in 2017 (Pyle and Schlick, 2016; Schlick and Pyle, 2017). These RNA challenges that we discuss in our workshops and in this special collection have produced many innovative multidisciplinary approaches to analyze, predict, simulate, and design RNA molecules. Large RNAs, such as the genome of the covid-19 virus, pose special challenges. We will undoubtedly witness more innovations in this connection in the near future. I look forward to discussing these developments in future in-person RNA meetings.