para-Selective Alkylation of Benzamides and Aromatic Ketones by Cooperative Nickel/Aluminum Catalysis
para-Selective Alkylation of Benzamides and Aromatic Ketones by Cooperative Nickel/Aluminum Catalysis
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DOI：
10.1021/jacs.6b08767
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发表时间：
2016-11-09
影响因子：
15
通讯作者：
Nakao, Yoshiaki
中科院分区：
文献类型：
--
作者：
Okumura, Shogo;Tang, Shuwei;Nakao, Yoshiaki
我们报道了一种方法，确保苯甲酰胺和芳香酮的对位选择性烷基化，通过协同镍/铝催化。使用大体积催化剂/助催化剂系统允许苯甲酰胺和烯烃之间的反应，以提供相应的对位烷基化产物。高对位选择性的起源也被调查的密度泛函理论计算。
We report a method that ensures the selective alkylation of benzamides and aromatic ketones at the para-position via cooperative nickel/aluminum catalysis. Using a bulky catalyst/cocatalyst system allows reactions between benzamides and alkenes to afford the corresponding para-alkylated products. The origin of the high para-selectivity has also been investigated by density functional theory calculations.