DISTINCT ANTIGEN RECEPTOR REPERTOIRES OF 2 CLASSES OF MURINE EPITHELIUM-ASSOCIATED T-CELLS
DISTINCT ANTIGEN RECEPTOR REPERTOIRES OF 2 CLASSES OF MURINE EPITHELIUM-ASSOCIATED T-CELLS
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DOI：
10.1038/341060a0
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发表时间：
1989-09-07
期刊：
影响因子：
64.8
通讯作者：
ALLISON, JP
中科院分区：
文献类型：
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作者：
ASARNOW, DM;GOODMAN, T;ALLISON, JP
淋巴细胞不仅是淋巴系统中的循环细胞，而且在某些上皮中也是固定细胞。α / β和γ / δ-异源二聚体亚型的t细胞抗原受体（TCR）都表现出极高的多样性。α / β TCRs的多样性源于大量可变(V)基因片段的使用，以及这些片段重排过程中产生的连接多样性，而γ / δ TCRs的多样性主要来自连接元件，有限数量的V基因片段贡献较小1。小鼠表皮和肠上皮中的许多T细胞表达由γ / δ异源二聚体组成的TCR 2 - 5,14,15。我们在这里证明，这两种组织中T细胞的γ/δ tcr在V基因的使用中受到限制，不同的元素占主导地位。然而，表皮T细胞的TCR连接多样性非常有限，而肠道T细胞的TCR连接多样性则非常丰富。这两个种群的独特特征表明，它们在特定的组织特异性功能上发育或被选择的方式不同。
TLYMPHOCYTES are found not only as recirculating cells in the lymphoid system, but also as immobile cells in certain epithelia. T-cell antigen receptors (TCR) of both α / β and γ / δ-heterodimer subtypes can exhibit an extremely high degree of diversity. The diversity of α / β TCRs derives from the use of a large number of variable (V) gene segments, as well as junctional diversity generated during rearrangement of these segments, whereas the diversity of γ / δ TCRs derives largely from junctional elements, with a smaller contribution from a limited number of V gene segments1. Many T cells in the epidermal and intestinal epithelia of mice express TCR composed of γ / δ heterodimers2–5,14,15. We demonstrate here that γ/δ TCRs of T cells in both these tissues are restricted in V gene usage, with different elements predominating. The TCR junctional diversity of epidermal T cells, however, is extremely limited, whereas that of intestinal T cells is extremely diverse. The distinctive features of these two populations suggest that they develop or are selected differently for particular tissue-specific functions.