A decrease in maternal plasma concentrations of sVEGFR-2 precedes the clinical diagnosis of preeclampsia
A decrease in maternal plasma concentrations of sVEGFR-2 precedes the clinical diagnosis of preeclampsia
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DOI：
10.1016/j.ajog.2010.04.002
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发表时间：
2010-06-01
影响因子：
9.8
通讯作者：
Hassan, Sonia S.
中科院分区：
文献类型：
--
作者：
Chaiworapongsa, Tinnakorn;Romero, Roberto;Hassan, Sonia S.
目的：本研究的目的是检查在诊断先兆子痫之前母体血浆可溶性血管内皮生长因子受体（sVEGFR）-2 浓度是否发生变化。 研究设计：对正常孕妇（n = 160）和先兆子痫患者（n = 40）进行了一项纵向研究。从 6 周到足月，每隔 7 个胎龄采集血样。通过酶联免疫吸附测定测定sVEGFR-2的血浆浓度。采用横断面和纵向（混合效应模型）方法进行分析。结果：注定要发生先兆子痫的母亲的血浆 sVEGFR-2 浓度低于正常妊娠的母亲（纵向方法；P < .05）。横断面分析表明，妊娠 28-31 周 (P = .001) 或诊断前 6-10 周 (P < .001) 的孕妇血浆 sVEGFR-2 浓度中位数显着低于正常孕妇。 结论：无论是足月还是早产，母体血浆 sVEGFR-2 浓度较低先于发生先兆子痫。
OBJECTIVE: The aim of this study was to examine if maternal plasma concentrations of soluble vascular endothelial growth factor receptor (sVEGFR)-2 change prior to the diagnosis of preeclampsia.STUDY DESIGN: A longitudinal study was conducted in normal pregnant women (n = 160) and patients with preeclampsia (n = 40). Blood samples were collected at 7 gestational age intervals from 6 weeks to term. Plasma concentrations of sVEGFR-2 were determined by enzyme-linked immunosorbent assay. Analysis was performed with cross-sectional and longitudinal (mixed effects model) approaches.RESULTS: Mothers destined to develop preeclampsia have lower plasma sVEGFR-2 concentrations than those who will have a normal pregnancy (longitudinal approach; P < .05). Cross-sectional analysis suggested that the median plasma sVEGFR-2 concentration in women destined to develop preeclampsia was significantly lower than that in normal pregnant women from 28-31 weeks of gestation (P = .001) or 6-10 weeks prior to the diagnosis (P < .001).CONCLUSION: A lower maternal plasma sVEGFR-2 concentration precedes the development of preeclampsia, both term and preterm.