Prevalence of dry eye in Bangkok, Thailand
Prevalence of dry eye in Bangkok, Thailand
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DOI：
10.1097/01.ico.0000244875.92879.1a
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发表时间：
2006-12-01
期刊：
影响因子：
2.8
通讯作者：
Vongthongsri, Anun
中科院分区：
文献类型：
--
作者：
Lekhanont, Kaevalin;Rojanaporn, Duangnate;Vongthongsri, Anun
目的：评估泰国曼谷成年人群中干眼症的患病率。
方法：招募了550名40岁及以上到拉玛提波迪医院进行年度眼部检查的志愿者。调查员发放了一份干眼症症状问卷。进行了裂隙灯检查以及包括泪膜破裂时间（TBUT）、荧光素角膜染色、希尔默试验和睑板腺评估在内的客观干眼症评估。结果指标包括症状出现频率和干眼症检测阳性情况。
结果：34%的人报告有明显症状，其定义为经常或一直有一个或多个症状（95%置信区间，28.1 - 40.6）。大约一半的人患有睑板腺疾病（MGD）或睑裂斑/翼状胬肉（分别为46.2%和53.8%）。有明显症状的个体往往是女性（83.4%，P = 0.024），患有MGD（63.6%，P = 0.006），正在使用人工泪液（33.2%，P = 0.024），TBUT阳性（80.7%，P = 0.000）以及荧光素染色阳性（16.6%，P = 0.013）。睑裂斑/翼状胬肉和MGD的存在与干眼症检测阳性显著相关。
结论：这是首次关于泰国老年人群中包括体征和症状在内的干眼症患病率的报告。根据症状和干眼症检测诊断出的疾病患病率比白人报告的大约高2到3倍。女性更有可能报告症状。在患有睑裂斑/翼状胬肉和MGD的受试者中发现与干眼症检测呈正相关。
Purpose: To estimate the prevalence of dry eye in the adult population of Bangkok, Thailand.Methods: Five hundred fifty volunteers 40 years of age or more who presented to the Ramathibodi Hospital for annual eye examinations were enrolled. Interviewers administered a dry eye symptoms questionnaire. Slit-lamp examination and objective dry eye assessment consisting of tear film breakup time (TBUT), fluorescein corneal staining, Schirmer tests, and meibomian gland evaluation were performed. Outcome measures included frequency of symptoms and positive dry eye tests.Results: Thirty-four percent reported significant symptoms, which were defined as having one or more symptoms often or a] I of the time (95% confidence interval, 28.1-40.6). Approximately one half had meibomian gland disease (MGD) or pingueculum/pterygium (46.2 and 53.8%, respectively). Individuals with significant symptoms tended to be women (83.4%, P = 0.024), had MGD (63.6%, P = 0.006), had current artificial tear use (33.2%, P = 0.024), and had positive TBUT (80.7%, P = 0.000) and fluorescein staining (16.6%, P = 0.013.) The presence of pingueculum/pterygium and MGD were significantly associated with positive dry eye tests.Conclusion: This is the first report of prevalence of dry eye inclusive of signs and symptoms in an elderly Thai population. The prevalence of disease diagnosed on the basis of symptoms and dry eye tests was approximately 2 to 3 times higher than reported in whites. Women were more likely to report symptoms. Positive associations with dry eye tests were found in subjects with pingucculum/pterygium and MGD.