The Impact of Intermittent Hypoxemia on Type 1 Retinopathy of Prematurity in Preterm Infants.
The Impact of Intermittent Hypoxemia on Type 1 Retinopathy of Prematurity in Preterm Infants.
复制标题
间歇性低氧血症对早产儿 1 型视网膜病变的影响。
DOI：
10.1101/2023.09.25.23295922
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
AbuJawdeh,ElieG
中科院分区：
文献类型：
--
作者：
Haratbar,SamanehRabienia;Chen,Li;Cheng,Qiang;Singh,Dara;Fathi,Faraneh;Mohtasebi,Mehrana;Liu,Xuhui;Patwardhan,Abhijit;Bhandary,Prasad;Bada,HenriettaS;Yu,Guoqiang;AbuJawdeh,ElieG
背景间歇性低氧血症（IH）可能影响早产儿视网膜病变（ROP）的发生，然而，以往的研究结果不一。这项研究测试的假设，增加IH与1型ROP;一个阶段，超过该阶段的治疗是indicated.MethodsIH进行了量化，连续监测血氧饱和度（SpO 2），使用高分辨率脉搏血氧饱和度计在第一个10周的生活。统计分析评估的关系和预测能力，每周和累积IH 1型ROP development.ResultsMost分析表明，IH和1型ROP调整胎龄（GA）和出生体重（BW）之间没有关联。然而，在第5-10、6-10和7-10周期间较长持续时间的累积IH与调整GA和BW的1型ROP显著相关，例如，从第6-10周，IH持续时间每增加3.8秒，1型ROP的调整优势比为2.01（p= 0.03）。IH没有提供统计学上显着增加预测能力以上GA和BW。ConclusionsFor大多数分析有IH和1型ROP调整GA和BW之间没有显着关联。然而，出生后第二个月内持续时间较长的婴儿发生1型ROP的风险较高。影响间歇性低氧血症（IH）与早产儿视网膜病变（ROP）的关系和预测能力存在争议。本研究显示，在调整胎龄（GA）和出生体重（BW）后，IH事件与1型ROP之间无显著相关性。除了在生命的第二个月内持续时间较长的累积IH。在这个队列中，IH并没有提供一个在统计学上显着改善ROP预测GA和BW。这项研究是第一个评估IH措施对1型ROP的累积影响。在出生后关键时期减少IH持续时间的干预措施可能会改善ROP结局。
BackgroundIntermittent hypoxemia (IH) may influence retinopathy of prematurity (ROP) development in preterm infants, however, previous studies had mixed results. This study tests the hypothesis that increased IH is associated with Type 1 ROP; a stage beyond which treatment is indicated.MethodsIH was quantified by continuously monitoring oxygen saturation (SpO2) using high-resolution pulse oximeters during the first 10 weeks of life. Statistical analyses assessed the relationship and predictive ability of weekly and cumulative IH for Type 1 ROP development.ResultsMost analyses showed no association between IH and Type 1 ROP adjusting for gestational age (GA) and birth weight (BW). However, cumulative IH of longer duration during weeks 5–10, 6–10, and 7–10 were significantly associated with Type 1 ROP adjusting for GA and BW, e.g., the adjusted odds ratio of Type 1 ROP was 2.01 (p= 0.03) for every 3.8 seconds increase in IH duration from week 6–10. IH did not provide statistically significant added predictive ability above GA and BW.ConclusionsFor most analyses there was no significant association between IH and Type 1 ROP adjusting for GA and BW. However, infants with longer IH duration during the second month of life had higher risk for Type 1 ROP.ImpactThe relationship and predictive ability of intermittent hypoxemia (IH) on retinopathy of prematurity (ROP) is controversial.This study shows no significant association between IH events and Type 1 ROP after adjusting for gestational age (GA) and birth weight (BW), except for cumulative IH of longer duration in the second month of life.In this cohort, IH does not provide a statistically significant improvement in ROP prediction over GA and BW.This study is the first to assess the cumulative impact of IH measures on Type 1 ROP. Interventions for reducing IH duration during critical postnatal periods may improve ROP outcomes.