Interleukin-6 as a potential indicator for prevention of high-risk adenoma recurrence by dietary flavonols in the polyp prevention trial.
Interleukin-6 as a potential indicator for prevention of high-risk adenoma recurrence by dietary flavonols in the polyp prevention trial.
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DOI：
10.1158/1940-6207.capr-09-0161
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发表时间：
2010-06
期刊：
影响因子：
--
通讯作者：
Cross AJ
中科院分区：
文献类型：
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作者：
Bobe G;Albert PS;Sansbury LB;Lanza E;Schatzkin A;Colburn NH;Cross AJ
血清白细胞介素 (IL)-6 是一种促炎细胞因子，被认为是炎症的指标，鉴于炎症可以促进癌变，因此可能是结直肠癌发生的指标。水果和蔬菜中含有的黄酮醇可能部分通过抑制炎症来抑制结直肠癌的发生。我们估计了比值比 (OR) 和 95% 置信区间 (CI)，以确定血清 IL-6 是否与结直肠腺瘤复发和黄酮醇摄入量相关，因此可以作为风险指标和膳食黄酮醇的反应指标。测量了来自息肉预防试验干预组的 872 名参与者在基线、第 1 年和第 3 年的血清 IL-6 浓度，该试验为期 4 年，旨在检验低脂肪、高纤维、高水果和蔬菜饮食对腺瘤复发的有效性。黄酮醇的摄入量，尤其是异鼠李素、山奈酚和槲皮素，与血清 IL-6 浓度（黄酮醇摄入量最高与最低四分位，1.80 与 2.20 pg/mL）、高风险（OR = 0.51，95% CI：0.26–0.98）和晚期腺瘤复发（OR = 0.17，95% CI：0.06–0.50）。试验期间IL-6浓度的降低与高风险（OR = 0.44，95% CI：0.23-0.84）和晚期腺瘤复发（OR = 0.47，95% CI：0.19-1.18）呈负相关。基线后黄酮醇摄入量高于中值且 IL-6 变化等于或低于中值的个体，高风险和晚期腺瘤复发的风险最低。我们的结果表明，血清 IL-6 可以作为预防结直肠癌的风险指标和膳食黄酮醇的反应指标。
Serum interleukin (IL)-6, a pro-inflammatory cytokine, is considered an indicator of inflammation and may be an indicator of colorectal carcinogenesis given that inflammation can promote carcinogenesis. Flavonols, which can be found in fruits and vegetables, may inhibit colorectal carcinogenesis partly by inhibiting inflammation. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) to determine whether serum IL-6 was associated with colorectal adenoma recurrence and flavonol intake and, thus may serve as a risk indicator and as a response indicator to dietary flavonols. Serum IL-6 concentrations at baseline, year 1 and 3 were measured in 872 participants from the intervention arm of the Polyp Prevention Trial, a 4-year trial that examined the effectiveness of a low-fat, high-fiber, high-fruit and vegetable diet on adenoma recurrence. Intake of flavonols, especially of isorhamnetin, kaempferol, and quercetin, was inversely associated with serum IL-6 concentrations (highest vs. lowest flavonol intake quartile, 1.80 vs. 2.20 pg/mL) and high risk (OR = 0.51, 95% CI: 0.26–0.98) and advanced adenoma recurrence (OR = 0.17, 95% CI: 0.06–0.50). A decrease in IL-6 concentration during the trial was inversely associated with high risk (OR = 0.44, 95% CI: 0.23–0.84) and advanced adenoma recurrence (OR = 0.47, 95% CI: 0.19–1.18). Individuals with above median flavonol intake and equal or below median IL-6 change after baseline had the lowest risk of recurrence of high risk and advanced adenoma. Our results suggest that serum IL-6 may serve as a risk indicator and as a response indicator to dietary flavonols for colorectal cancer prevention.