Supramolecular hydrogels with multi-cylindrical lamellar bilayers: Swelling-induced contraction and anisotropic molecular diffusion
Supramolecular hydrogels with multi-cylindrical lamellar bilayers: Swelling-induced contraction and anisotropic molecular diffusion
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DOI：
10.1016/j.polymer.2017.01.038
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发表时间：
2017-10-16
期刊：
影响因子：
4.6
通讯作者：
Gong, Jian Ping
中科院分区：
文献类型：
--
作者：
Mito, Kei;Haque, Md. Anamul;Gong, Jian Ping
本研究提出了一种新型的、超分子的、各向异性的水凝胶（称为MC-PDGI凝胶）。这些MC-PDGI凝胶由以单轴方式排列并嵌入软水凝胶基质中的多圆柱形脂质双层组成。由于氢键作用，双层和水凝胶之间的相互作用很弱。这些MC-PDGI凝胶在暴露于水后膨胀，这导致它们的体积和直径增加，同时导致它们的长度减少。这种各向异性溶胀诱导的收缩行为是水凝胶基质的各向同性弹性与脂质双层的界面张力之间竞争的结果。此外，MC-PDGI凝胶表现出独特的准一维扩散行为，由于分子渗透通过多层脂质双层的困难。这些材料可用于延长药物释放或作为致动器。(C)2017爱思唯尔有限公司版权所有。
Novel, supramolecular, anisotropic hydrogels (called MC-PDGI gels) are presented in this study. These MC-PDGI gels consist of multi-cylindrical lipid bilayers aligned in a uniaxial manner and embedded in a soft hydrogel matrix. The bilayers and the hydrogel interact weakly due to hydrogen bonding. These MC-PDGI gels swell after exposure to water, which causes their volume and diameter to increase while simultaneously causing their length to decrease. This anisotropic swelling-induced contraction behavior is the result of competition between the isotropic elasticity of the hydrogel matrix and the interfacial tension of the lipid bilayers. Moreover, the MC-PDGI gels exhibit unique quasi one-dimensional diffusion behavior owing to the difficulty of molecular penetration through the multi-layered lipid bilayers. These materials would be useful for prolonged drug release or as an actuator. (C) 2017 Elsevier Ltd. All rights reserved.