ABERRANT BREAKPOINTS IN CHRONIC MYELOGENOUS LEUKEMIA - ONCOGENES AND FRAGILE SITES
ABERRANT BREAKPOINTS IN CHRONIC MYELOGENOUS LEUKEMIA - ONCOGENES AND FRAGILE SITES
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DOI：
10.1007/bf00280504
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发表时间：
1986-12-01
期刊：
影响因子：
5.3
通讯作者：
HENRYAMAR, M
中科院分区：
文献类型：
--
作者：
HURET, JL;TANZER, J;HENRYAMAR, M
本文综述了慢性髓性白血病伴费城染色体变异的325个异常断点。发现8条染色体带（3p21、6p21、7p22、11q13、12p13、17p13、17q21和17q25）高度相关。除17q25外，所有这些条带都对应于癌基因位点和/或作为癌症主要断点的位点。
Three hundred and twenty-five aberrant breakpoints in chronic myelogenous leukaemia (CML) with Philadelphia chromosome variant were reviewed. Eight chromosomal bands (3p21, 6p21, 7p22, 11q13, 12p13, 17p13, 17q21, and 17q25) were found to be highly involved. Apart from 17q25, all these bands correspond to oncogenes sites and/or sites involved as primary breakpoints in cancer.