Biomonitoring human urinary levels of 26 metal elements in multi-race coexistence region of Xinjiang, China
Biomonitoring human urinary levels of 26 metal elements in multi-race coexistence region of Xinjiang, China
复制标题
中国新疆多种族共存地区人体尿液中26种金属元素的生物监测
DOI：
10.1016/j.scitotenv.2019.134752
复制
发表时间：
2020
影响因子：
9.8
通讯作者：
Feng Shun
中科院分区：
文献类型：
--
作者：
Shi Haizhu;Wang Jingjing;Yuan Jie;Tan Xiaopei;Wang Xinxing;Chen Cheng;Feng Shun
金属（类金属）的人体生物监测是重要的，其浓度可以指示广泛的健康相关信息。在进行准确的统计评价时，严格要求特定群体基质中金属（类金属）的参考值（RV）。最近的研究表明，金属（类金属）的RV受到许多因素的影响，包括生活方式，饮食，不同的环境，位置以及种族。然而，在许多国家/地区，特别是多种族共存的地区，它几乎不存在。目的：建立新疆地区成人尿中金属（类金属）的相对含量。采用电感耦合等离子体质谱仪（ICP-MS/OES）对178例健康志愿者尿液进行分析。建立了新疆地区成人尿中26种金属（类金属）的相对标准偏差。采用偏最小二乘判别分析和Student t检验分析种族、性别和年龄对RVs的影响。结果表明，上述因素对RV的建立影响较小。178份成人尿标本（汉族和维吾尔族各占一半）的RV可用于不同种族、性别和年龄段。此外，据观察，三种金属（类金属），砷，钪和钡显着变化之间的一些小组。本研究所建立的RV对未来的健康或环境评估具有一定的参考价值，并可为多种族共存地区RV的建立提供理论参考。
The human biological monitoring of metals (metalloids) is of importance, which concentrations could indicate a wide range of health related information. Reference values (RVs) of metals (metalloids) in specific matix of populations are critically required when performing a statistical evaluation accurately. Recent studies show that RVs of metals (metalloids) are influenced by many multiple factors, including lifestyle, diet, dissimilar environment, location, as well as race. However, it is virtually absent across many nations/regions, especially multi-race coexistence regions. The aim of the work was to establish RVs of metals (metalloids) in urine of adult in Xinjiang, China. Totally 178 urine samples from healthy volunteers were collected and analyzed by inductively coupled plasma mass spectrometer or optical emission spectrometer (ICP-MS/OES). RVs of 26 metals (metalloids) in urine for adult of Xinjiang, China were then established. Effects of race, gender and age on RVs were investigated using partial least squares discriminant analysis and student T-test. The result demonstrated that above factors showed mild influence for the establishment of RVs. The RVs derived from total 178 urine adult samples (Han and Uygur half of each) can be applied for different race, gender and age periods. Moreover, it was observed that three metals (metalloids), As, Sc and Ba significantly varied between some subgroups. The established RVs will be valuable for future health or environmental evaluation, and can serve as a theoretical reference for RVs establishment in multi-race coexistence region.