Valuations of EQ-5D health states - Are the United States and United kingdom different?
Valuations of EQ-5D health states - Are the United States and United kingdom different?
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DOI：
10.1097/00005650-200503000-00004
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发表时间：
2005-03-01
期刊：
影响因子：
3
通讯作者：
Coons, SJ
中科院分区：
文献类型：
--
作者：
Johnson, JA;Luo, N;Coons, SJ
目的：我们试图比较美国和英国普通成年人口之间 EQ-5D 健康状态的直接引出估值。方法：我们分析了 2 项 EQ-5D) 估值研究的数据，其中使用类似的时间权衡协议，从美国和英国普通成年人口的代表性样本中得出 42 种常见健康状态的值。首先，对美国和英国每个健康州的人口平均估值进行了估计和比较。其次，使用随机效应模型比较美国和英国的估值，同时调整 EQ-5D 估值的已知预测因素（即年龄、性别、健康状况描述符），并调查估值是否存在差异以及如何差异。结果：美国 42 个健康州的人口平均估值范围为 -0.38 至 0.88，英国为 -0.54 至 0.88，美国的平均得分在数值上高于英国39 种健康状态（平均差：0. 11；范围：- 0.0 1 至 0.25）。在调整已知预测变量的主效应后，估值的平均差异为 0.10 (P < 0.001)。在 EQ-5D) 健康州中，美国和英国估值差异的大小并不恒定；以极端问题为特征的健康状况存在较大的评估差异。结论：美国和英国普通人群之间直接得出的 EQ-5D 健康状况 TTO 评估存在显着差异。因此，根据美国普通民众的估值生成的 EQ-5D 指数评分应用于旨在反映美国普通公众健康状况偏好的研究。
Purpose: We sought to compare directly elicited valuations for EQ-5D health states between the US and UK general adult populations.Methods: We analyzed data from 2 EQ-5D) valuation studies where, using similar time trade-off protocols, values for 42 common health states were elicited from representative samples of the US and UK general adult populations. First, US and UK population mean valuations were estimated and compared for each health state. Second, random-effect models were used to compare the US and UK valuations while adjusting for known predictors of EQ-5D valuations (ie, age, sex, health state descriptors) and to investigate whether and how the valuations differ.Results: Population mean valuations of the 42 health states ranged from -0.38 to 0.88 for the United States and from -0.54 to 0.88 for the United Kingdom, with the US mean scores being numerically higher than the UK for 39 health states (mean difference: 0. 11; range: - 0.0 1 to 0.25). After adjusting for the main effects of known predictors, the average difference in valuations was 0.10 (P < 0.001). The magnitude of the difference in the US and UK valuations was not constant across EQ-5D) health states; greater differences in valuations were present in health states characterized by extreme problems.Conclusions: Meaningful differences exist in directly elicited TTO valuations of EQ-5D health states between the US and UK general populations. Therefore, EQ-5D index scores generated using valuations from the US general population should be used for studies aiming to reflect health state preferences of the US general public.