Rheumatoid arthritis is an autoimmune disease triggered by Proteus urinary tract infection
Rheumatoid arthritis is an autoimmune disease triggered by Proteus urinary tract infection
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DOI：
10.1080/17402520600576578
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发表时间：
2006-03-01
影响因子：
--
通讯作者：
Rashid, Taha
中科院分区：
文献类型：
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作者：
Ebringer, Alan;Rashid, Taha
类风湿性关节炎（rheumatoid arthritis，RA）是一种慢性致残性多关节炎性疾病，主要累及中老年女性。基于来自世界不同地区的各种微生物，免疫学和分子研究结果的广泛证据表明，奇异变形杆菌微生物与RA之间存在密切联系。我们认为亚临床变形杆菌尿路感染是主要的触发因素，这些细菌和RA靶向组织抗原之间的分子模拟和交叉反应的存在通过产生细胞病变自身抗体有助于疾病过程的持续。RA患者，特别是在疾病的早期阶段，可以从变形杆菌抗菌措施中受益，包括使用抗生素，除了目前采用的治疗方法外，还需要素食和大量摄入水和果汁如蔓越莓汁。
Rheumatoid arthritis (RA) is a chronic and disabling polyarthritic disease, which affects mainly women in middle and old age. Extensive evidence based on the results of various microbial, immunological and molecular studies from different parts of the world, shows that a strong link exists between Proteus mirabilis microbes and RA. We propose that sub-clinical Proteus urinary tract infections are the main triggering factors and that the presence of molecular mimicry and cross-reactivity between these bacteria and RA-targeted tissue antigens assists in the perpetuation of the disease process through production of cytopathic auto-antibodies.Patients with RA especially during the early stages of the disease could benefit from Proteus anti-bacterial measures involving the use of antibiotics, vegetarian diets and high intake of water and fruit juices such as cranberry juice in addition to the currently employed treatments.