Mechanochemical Adhesion and Plasticity in Multifiber Hydrogel Networks
Mechanochemical Adhesion and Plasticity in Multifiber Hydrogel Networks
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DOI：
10.1002/adma.201905719
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发表时间：
2019-12-18
影响因子：
29.4
通讯作者：
Burdick, Jason A.
中科院分区：
文献类型：
--
作者：
Davidson, Matthew D.;Ban, Ehsan;Burdick, Jason A.
细胞外基质（ECM）具有力响应性（即，机械化学）性质，其能够通过纤维网络结构和纤维间粘合的变化来适应机械负荷。将这些特性赋予合成纤维材料将允许在机械负荷下增强、材料自粘附的可能性以及ECM的一般模仿。多纤维水凝胶网络通过多个纤维水凝胶群体的静电纺丝而形成，其中纤维含有互补的化学部分（例如，醛和酰肼基团），当在机械负荷下接触时，在几分钟内形成共价键。这些纤维相互作用导致微尺度各向异性，以及增加的材料刚度和塑性变形。宏观结构（例如，管和层状支架）由这些材料制成，当放置成接触时，通过纤维间结合和粘合，同时保持微尺度纤维结构。所描述的工程塑性设计原理可以应用于许多材料系统，以引入独特的性能，从纺织品到生物医学应用。
The extracellular matrix (ECM) has force-responsive (i.e., mechanochemical) properties that enable adaptation to mechanical loading through changes in fibrous network structure and interfiber bonding. Imparting such properties into synthetic fibrous materials will allow reinforcement under mechanical load, the potential for material self-adhesion, and the general mimicking of ECM. Multifiber hydrogel networks are developed through the electrospinning of multiple fibrous hydrogel populations, where fibers contain complementary chemical moieties (e.g., aldehyde and hydrazide groups) that form covalent bonds within minutes when brought into contact under mechanical load. These fiber interactions lead to microscale anisotropy, as well as increased material stiffness and plastic deformation. Macroscale structures (e.g., tubes and layered scaffolds) are fabricated from these materials through interfiber bonding and adhesion when placed into contact while maintaining a microscale fibrous architecture. The design principles for engineering plasticity described can be applied to numerous material systems to introduce unique properties, from textiles to biomedical applications.