A 10-year, prospective study of the metabolic effects of growth hormone replacement in adults
A 10-year, prospective study of the metabolic effects of growth hormone replacement in adults
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DOI：
10.1210/jc.2006-1487
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发表时间：
2007-04-01
影响因子：
5.8
通讯作者：
Svensson, J.
中科院分区：
文献类型：
--
作者：
Gotherstrom, G.;Bengtsson, B. -A.;Svensson, J.
内容：只有少数研究调查了生长激素替代治疗在成人超过5 yr.Objective/Design/Patients的影响：在一项前瞻性，开放标签，单中心研究，10年生长激素替代治疗的影响进行了测定。87例连续患者（52名男性和35名女性），平均年龄为44.1（范围22-74）年与成人发病的GH缺乏症（GHD.Results：GH的初始平均剂量（0.98 mg/d）在研究期间减少，在第10年为0.47 mg/d。平均IGF-I SD评分从基线时的-1.81增加至研究结束时的1.29。全身脂肪的绝对减少是短暂的。然而，在使用四房室模型校正年龄和性别后，在10年的研究期间，体脂的减少是持续的。血脂水平持续改善，10年后，糖化血红蛋白水平降低。治疗反应IGF-I SD评分，血清高密度脂蛋白胆固醇水平，身体成分使用双能X射线吸收测定法测量的男性更显着，而女性有一个更显着的减少血液糖化血红蛋白level.Conclusion：对身体脂肪的绝对量的影响是早期和短暂的，这可能是由于正常的年龄的患者。对代谢指标的影响后来才被发现，但它们在整个研究期间是持续的，甚至是渐进的。
Context: Only a few studies have investigated the effects of GH replacement in adults for more than 5 yr.Objective/Design/Patients: In a prospective, open-label, single-center study, the effects of 10-yr GH replacement were determined. Eighty-seven consecutive patients (52 men and 35 women), with a mean age of 44.1 (range 22-74) yr with adult-onset GH deficiency (GHD) were included.Results: The initial mean dose of GH (0.98 mg/d) was reduced during the study and at yr 10 was 0.47 mg/d. The mean IGF-I SD score increased from -1.81 at baseline to 1.29 at study end. The absolute reduction in total body fat was transient. However, after correction for age and sex using a four-compartment model, the reduction in body fat was sustained during the 10-yr study period. There was a sustained improvement in serum lipid profile and after 10 yr, and blood glycosylated hemoglobin level was reduced. The treatment responses in IGF-I SD score, serum high-density lipoprotein cholesterol level, and body composition as measured using dual-energy x-ray absorptiometry were more marked in men, whereas women had a more marked reduction in blood glycosylated hemoglobin level.Conclusion: The effect on the absolute amount of body fat was seen early and was transient, which could be due to the normal aging of the patients. The effects on metabolic indices were detected later, but they were sustained and even progressive throughout the study period.