The GABAB receptor agonists baclofen and CGP 44532 prevent acquisition of alcohol drinking behaviour in alcohol-preferring rats
The GABAB receptor agonists baclofen and CGP 44532 prevent acquisition of alcohol drinking behaviour in alcohol-preferring rats
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DOI：
10.1093/alcalc/37.5.499
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发表时间：
2002-09-01
影响因子：
2.8
通讯作者：
Gessa, GL
中科院分区：
文献类型：
--
作者：
Colombo, G;Serra, S;Gessa, GL
目的：本研究调查了 γ-氨基丁酸 (GABA)(B) 受体激动剂巴氯芬和 CGP 44532 对选择性繁殖的撒丁岛嗜酒 (sP) 大鼠饮酒行为的影响。方法：在给初次接触酒精的 sP 大鼠饮酒前立即给予巴氯芬 [0、1 和 3 mg/kg，腹膜内 (i.p.)] 和 CGP 44532（0、0.1、0.3 和 1 mg/kg，i.p.）。酒精饮料按照两瓶自由选择方案提供，每天 24 小时无限量饮用。药物治疗每天重复一次，连续10天。结果：巴氯芬和 CGP 44532 抑制酒精摄入，剂量依赖性且具有相当的功效；水摄入量的代偿性增加使得总液体摄入量几乎没有变化。结论：这些结果表明，巴氯芬和 CGP 44532 可防止 sP 大鼠获得饮酒行为，并表明 GABA(B) 受体参与该大鼠系中酒精增强特性的揭示和体验的机制。
Aims: The present study investigated the effect of the gamma-aminobutyric acid (GABA)(B) receptor agonists, baclofen and CGP 44532, on the acquisition of alcohol drinking behaviour in selectively bred Sardinian alcohol-preferring (sP) rats. Methods: Baclofen [0, 1 and 3 mg/kg, intraperitoneally (i.p.)] and CGP 44532 (0, 0.1, 0.3 and 1 mg/kg, i.p.) were administered immediately before alcohol presentation to alcohol-naive sP rats. Alcohol was offered under the two-bottle free-choice regimen with unlimited access for 24 h/day. Drug treatment was repeated once daily for 10 consecutive days. Results: Baclofen and CGP 44532, dose-dependently and with comparable efficacy, suppressed alcohol intake; compensatory increases in water intake left total fluid intakes virtually unchanged. Conclusions: These results demonstrate that baclofen and CGP 44532 prevent the acquisition of alcohol drinking behaviour in sP rats, and suggest the involvement of the GABA(B) receptor in the mechanisms underlying the disclosure and experience of the reinforcing properties of alcohol in this rat line.