Ferromagnetic nanoparticles for magnetic hyperthermia and thermoablation therapy
Ferromagnetic nanoparticles for magnetic hyperthermia and thermoablation therapy
复制标题
DOI：
10.1088/0022-3727/43/47/474011
复制
发表时间：
2010-12-01
影响因子：
3.4
通讯作者：
Ohkohchi, Nobuhiro
中科院分区：
文献类型：
--
作者：
Kita, Eiji;Oda, Tatsuya;Ohkohchi, Nobuhiro
在纳米生物医学领域，铁磁纳米粒子用于热疗和热消融治疗已经显示出巨大的前景。即使是局部热疗作为一种新的癌症治疗方法也具有许多优点;然而，它需要超过1 kW g（-1）的显着高加热功率用于加热剂。作为高发热的候选者，我们专注于铁磁纳米粒子，并将其物理性质与超顺磁性物质进行比较。对具有立方磁对称性和单轴磁对称性的理想单畴铁磁纳米颗粒进行了数值模拟，得到了具有小回线的MH曲线。从模拟，有效地使用具有有限的振幅的交变磁场（AMF）进行了讨论。采用共沉淀法和水热法制备了具有不同矫顽力的钴铁氧体纳米粒子。在117 kHz、H 0 = 51.4 kAm 1（640 Oe）时，AMF的最大比损耗功率为420 W g（-1）。在铁磁状态下的弛豫行为低于超顺磁性阻断温度进行了检查穆斯堡尔谱。
The use of ferromagnetic nanoparticles for hyperthermia and thermoablation therapies has shown great promise in the field of nanobiomedicine. Even local hyperthermia offers numerous advantages as a novel cancer therapy; however, it requires a remarkably high heating power of more than 1 kW g(-1) for heat agents. As a candidate for high heat generation, we focus on ferromagnetic nanoparticles and compare their physical properties with those of superparamagnetic substances. Numerical simulations for ideal single-domain ferromagnetic nanoparticles with cubic and uniaxial magnetic symmetries were carried out and MH curves together with minor loops were obtained. From the simulation, the efficient use of an alternating magnetic field (AMF) having a limited amplitude was discussed. Co-ferrite nanoparticles with various magnitudes of coercive force were produced by co-precipitation and a hydrothermal process. A maximum specific loss power of 420 W g(-1) was obtained using an AMF at 117 kHz with H-0 = 51.4 kA m(-1) (640 Oe). The relaxation behaviour in the ferromagnetic state below the superparamagnetic blocking temperature was examined by Mossbauer spectroscopy.