Functional MR imaging assessment of tumor response after 90Y microsphere treatment in patients with unresectable hepatocellular carcinoma
Functional MR imaging assessment of tumor response after 90Y microsphere treatment in patients with unresectable hepatocellular carcinoma
复制标题
DOI：
10.1016/j.jvir.2006.10.005
复制
发表时间：
2007-01-01
影响因子：
2.9
通讯作者：
Geschwind, Jean-Francois H.
中科院分区：
文献类型：
--
作者：
Kamel, Ihab R.;Reyes, Diane K.;Geschwind, Jean-Francois H.
目得：评价功能性造影剂增强和弥散加权磁共振成像（MR）在评价不可切除的肝细胞癌（HCC）对钇-90标记微球单次治疗的早期（1个月）反应中的效用。材料和方法：作者评价了13名连续患者在单次选择性Y-90微球治疗前和治疗后1个月获得的MR图像（平均年龄62岁）。所有患者均有肝硬化和病理证实的HCC。图像由两名放射科医生一致评价。记录治疗前后肿瘤大小、动静脉强化及表观弥散系数（ADC）。在每例患者中包括治疗的肝叶中的一个靶向肿瘤。在对侧肝叶也有病变的患者中，第二个肿瘤被列为非靶向肿瘤。结果：13例患者中有19个肿瘤（平均肿瘤大小为9.4 cm）。平均肿瘤负荷为总肝脏体积的25%。靶向肿瘤（n = 13）显示动脉增强平均降低22%（P = 0.013），静脉增强平均降低25%（P = 0.012），ADC值平均增加18%（P
PURPOSE: To assess the utility of functional contrast medium-enhanced and diffusion-weighted magnetic resonance (MR) imaging in the assessment of early (1 month) response of unresectable hepatocellular carcinoma (HCC) to a single treatment with yttrium-90-labeled microspheres.MATERIALS AND METHODS: The authors evaluated the MR images obtained before and 1 month after single selective Y-90 microsphere treatment in 13 consecutive patients (mean age, 62 years). All patients had cirrhosis and pathologically proved HCC. Images were evaluated by consensus of two radiologists. Tumor size, arterial and venous enhancement, and apparent diffusion coefficient (ADC) were recorded before and after treatment. One targeted tumor in the treated lobe of the liver was included in each patient. In patients who also had lesions in the contralateral lobe of the liver, a second tumor was included as nontargeted tumor.RESULTS: There were 19 tumors in the 13 patients (mean tumor size, 9.4 cm). The mean tumor burden was 25% of the total liver volume. Targeted tumors (n = 13) demonstrated a mean decrease in arterial enhancement of 22% (P =.013), a mean decrease in venous enhancement of 25% (P =.012), and a mean increase in ADC value of 18% (P