Cytokines across the Night in Chronic Fatigue Syndrome with and without Fibromyalgia
Cytokines across the Night in Chronic Fatigue Syndrome with and without Fibromyalgia
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DOI：
10.1128/cvi.00379-09
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发表时间：
2010-04-01
影响因子：
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通讯作者：
Natelson, Benjamin H.
中科院分区：
文献类型：
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作者：
Nakamura, Toru;Schwander, Stephan K.;Natelson, Benjamin H.
慢性疲劳综合征(CFS)的症状与细胞因子失调相一致。这导致了免疫失调是这种疾病的原因的假说。为了进一步验证这一假设，当患者和匹配的健康对照组在睡眠实验室睡觉时，我们对细胞因子进行了重复的血液采样。因为没有一种检测细胞因子的方法被认为比另一种方法更好，所以我们检测了血清中的蛋白质、外周血淋巴细胞(PBL)中的信息以及静息和刺激PBL的功能。我们没有发现促炎细胞因子上调的证据。相反，与我们早期的一些研究一致，我们确实发现了一些证据，支持抗炎细胞因子白细胞介素10的增加。尽管这些变化很小，但它们可能导致CFS患者普遍抱怨睡眠中断。
The symptoms of chronic fatigue syndrome (CFS) are consistent with cytokine dysregulation. This has led to the hypothesis of immune dysregulation as the cause of this illness. To further test this hypothesis, we did repeated blood sampling for cytokines while patients and matched healthy controls slept in the sleep lab. Because no one method for assaying cytokines is acknowledged to be better than another, we assayed for protein in serum, message in peripheral blood lymphocytes (PBLs), and function in resting and stimulated PBLs. We found no evidence of proinflammatory cytokine upregulation. Instead, in line with some of our earlier studies, we did find some evidence to support a role for an increase in interleukin-10, an anti-inflammatory cytokine. Although the changes were small, they may contribute to the common complaint in CFS patients of disrupted sleep.