Malabsorption of bile acids in children with cystic fibrosis.
Malabsorption of bile acids in children with cystic fibrosis.
复制标题
囊性纤维化儿童胆汁酸吸收不良。
DOI：
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发表时间：
1973
影响因子：
158.5
通讯作者：
R. Lasalle
中科院分区：
文献类型：
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作者：
A. Weber;C. Roy;C. Morin;R. Lasalle
摘要24例继发于囊性纤维化的胰腺功能不全患儿未经治疗，粪便胆汁酸定量（毫克/24小时/平方米体表面积）增加（743.2 ± 55.3 - mean ± S.E.）而12例乳糜泻和7例慢性非特异性腹泻与18例对照组的值（110.0 ± 11.0）无差异。囊性纤维化患者的胆汁酸丢失量与回肠切除术后的6名婴儿相当（957.7 ± 195.1）。在5例囊性纤维化患者中，当停止胰酶治疗时，粪便胆汁酸大量增加（p<0.01）。这些数据以及在囊性纤维化中发现的粪便脂肪和胆汁酸之间的良好相关性（r = 0.78），而在乳糜泻中未发现，表明未水解脂肪或其他消化不良产物可能会干扰胆汁酸吸收。在胰腺补充期间研究的两例囊性纤维化患者中发现的每日粪便胆汁酸螯合量为1.9 g和3.7 g，表明胰腺补充治疗可改善囊性纤维化的症状。
Abstract Quantitative fecal bile acids (in milligrams per 24 hours per square meter of body-surface area) in 24 children with untreated pancreatic insufficiency secondary to cystic fibrosis were increased (743.2 ± 55.3 — mean ± S.E.) whereas those in 12 cases of celiac disease and in seven with chronic nonspecific diarrhea did not differ from values in 18 controls (110.0 ± 11.0). Bile acid loss in cystic fibrosis was comparable to that of six infants after ileal resection (957.7 ± 195.1). A large increase (p<0.01) in fecal bile acids occurred when pancreatic enzyme therapy was withdrawn in five patients with cystic fibrosis. These data and the good correlation (r = 0.78) found in cystic fibrosis and not in celiac disease between fecal fat and bile acids suggest that unhydrolyzed fat or other products of maldigestion may interfere with bile acid absorption. The daily fecal bile acid sequestration of 1.9 g and 3.7 g found in two cases of cystic fibrosis studied during pancreatic supplementation indicates th...